|
| Status |
Public on Feb 04, 2022 |
| Title |
MyoD-Cre driven alterations in K-Ras and p53 lead to a mouse model with histological and molecular characteristics of human rhabdomyosarcoma [RMS_GEMM_tumors] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We have developed a new conditional genetically engineered mouse model of rhabdomyosarcoma (RMS) with homologous molecular signature to human RMS that provides valuable pre-clinical models for evaluating novel therapies
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| |
|
| Overall design |
Mice expressing MyoD promoter-regulated Cre-recombinase were crossed with germline p53Flox or Lox-Stop-Lox (LSL) knock-in alleles expressing oncogenic p53R172H and/or K-RasG12D mutants.
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| |
|
| Contributor(s) |
Yustein JT, Nakahata K, Patel TD |
| Citation(s) |
35174853 |
| Submission date |
Feb 01, 2022 |
| Last update date |
Feb 23, 2022 |
| Contact name |
Jason T Yustein |
| E-mail(s) |
yustein@bcm.edu
|
| Organization name |
Texas Children's Hospital
|
| Department |
Pediatrics-Oncology
|
| Lab |
Suite 1025.07
|
| Street address |
1102 Bates Ave
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (10)
|
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| This SubSeries is part of SuperSeries: |
| GSE195923 |
MyoD-Cre driven alterations in K-Ras and p53 lead to a mouse model with histological and molecular characteristics of human rhabdomyosarcoma |
|
| Relations |
| BioProject |
PRJNA802674 |
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