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| Status |
Public on Dec 31, 2022 |
| Title |
Transcriptome profiling of left ventricles from Wildtype and KDM5B knockout mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Myocardial fibrosis is the most common pathological feather of adverse ventricular remodeling, and persistent fibrotic extension decreases myocardial compliance, promotes the development of heart failure. Epigenetics has been considered to play a potent regulatory role in the development of excessive myocardial fibrosis. Although, the explicit mechanism of epigenetic regulation in myocardial fibrosis still needs to be fully elucidated.Transcriptome microarray analysis was used to screen differentially expressed genes in myocardial tissues from KDM5B KO and littermate control WT mice at day 7 after MI operation.
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| Overall design |
8-10-week-old male KDM5B KO mice and their corresponding WT mice were subjected to myocardial infarction by ligation of the left anterior descending coronary artery. At 7 days after myocardial infarction, the left ventricular samples were harvested and total RNA was isolated for hybridization on agilent microarray. Each group contain with 2 replicates
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| Contributor(s) |
Wang B, Liu X, Zhan Z |
| Citation(s) |
36481938 |
| |
| Submission date |
Feb 22, 2022 |
| Last update date |
Jan 04, 2023 |
| Contact name |
Zhenzhen Zhan |
| E-mail(s) |
zhanzz@tongji.edu.cn
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| Organization name |
Shanghai East Hospital, Tongji University School of Medicine,
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| Department |
Research Center for Translational Medicine
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| Street address |
Jimo Road 150
|
| City |
Shanghai |
| ZIP/Postal code |
200120 |
| Country |
China |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA809385 |
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