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Series GSE198009 Query DataSets for GSE198009
Status Public on Jan 01, 2023
Title Transcriptomic study identifies quercetin and rutin as repurposed drugs for Parkinson’s Disease in in vitro 6-OHDA model
Organism Homo sapiens
Experiment type Expression profiling by array
Summary SH-SY5Y cells were treated with 6-hydroxydopamine (6-OHDA) to obtain an in vitro PD model. Transcriptome data were collected from both treated and untreated cells.We mapped significantly upregulated genes on a protein-protein interaction network to identify potential drug targets. Drugs targeting the selected drug targets were applied to 6-OHDA treated SH-SY5Y cells. Among the candidate drugs, quercetin and rutin were shown to be neuroprotective by effectively decreasing cell death.
 
Overall design In total, 16 independent experiments were performed to obtain 8 untreated samples and 8 6-OHDA treated samples. Samples were collected at 12th and 18th hours from both treated and control experiments. Each group was run in four replicates.
 
Contributor(s) Yigit EN, Sonmez E, Yuksel I, Cakir T, Aksan Kurnaz I
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Submission date Mar 06, 2022
Last update date Jan 03, 2023
Contact name Tunahan Cakir
E-mail(s) tcakir@gtu.edu.tr
Organization name Gebze Technical University
Department Department of Bioengineering
Street address Gebze, Kocaeli, Turkey
City Gebze
State/province Kocaeli
ZIP/Postal code 41400
Country Turkey
 
Platforms (1)
GPL20844 Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Feature Number Version]
Samples (16)
GSM5935748 SH-SY5Y, Control, 12hr, rep1
GSM5935749 SH-SY5Y, Control, 12hr, rep2
GSM5935750 SH-SY5Y, Control, 12hr, rep3
Relations
BioProject PRJNA813345

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE198009_RAW.tar 59.3 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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