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Series GSE199483 Query DataSets for GSE199483
Status Public on Mar 30, 2022
Title RNA-seq in H1299 cell lines
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Purpose: The goals of this study are to investigate the primary biological process of HNRNPC.
Methods: Briefly, samples (H1299 cells transfected with control or HNRNPC shRNA) were used to extract total RNAs for quality control and RNA-seq loading samples. RNA-seq was performed as DGE on an Illumia HiSeq platform and 50 bp paired-end reads were generated (BGI Co. Ltd.).
Results: RNA-seq in H1299 cell lines revealed that HNRNPC mainly regulated cell growth, cell migration, extracellular matrix organization, angiogenesis, collagen fibril organization, and T cell mediated cytotoxicity.
Conclusions: HNRNPC mainly regulated cell growth, cell migration, extracellular matrix organization, angiogenesis, collagen fibril organization, and T cell mediated cytotoxicity.
 
Overall design mRNA profiles of H1299 HNRNPC shNC cells and H1299 HNRNPC knockdown cells
 
Contributor(s) Gu Z
Citation(s)
  • Gu Z, Yang Y, Ma Q, Wang H et al. HNRNPC, a predictor of prognosis and immunotherapy response based on bioinformatics analysis, is related to proliferation and invasion of NSCLC cells. Respir Res 2022 Dec 19;23(1):362. PMID: 36536402
Submission date Mar 26, 2022
Last update date Jan 06, 2023
Contact name zhuoyu gu
E-mail(s) guzhuoyu@hotmail.com
Organization name First Affiliated Hospital of Zhengzhou University
Street address No. 50, Jianshe East Road, Erqi District
City Zhengzhou
State/province China
ZIP/Postal code 450052
Country China
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (6)
GSM5973996 H1299 cells, NC1, 1
GSM5973997 H1299 cells, NC1, 2
GSM5973998 H1299 cells, NC1, 3
Relations
BioProject PRJNA820274

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE199483_gene_diff.txt.gz 126.6 Kb (ftp)(http) TXT
GSE199483_gene_expression.txt.gz 117.6 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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