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| Status |
Public on Apr 04, 2023 |
| Title |
Hepatic irradiated pigs develop radiation induced veno-occlusive liver disease with ferroptosis |
| Organism |
Sus scrofa |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In this study, we performed a dose escalation study of whole-liver irradiation in miniature pigs and established a novel pig model for the severe form of RILD largely resembling the clinical and histological features of the human diseases, especially VOD and hepatic necrosis. Furthermore, taking advantage of serial liver biopsy in large-sized animal, we dissected the dynamics of cellular events essential for irreversible liver dysfunction in RILD. Unexpectedly, ferroptosis was also detected in irradiated pig liver samples.
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| Overall design |
We performed a whole-genome RNA-sequencing analysis of irradiated livers from the 20Gy, 30Gy,40Gy treated and control pigs
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| Contributor(s) |
Wang Y, Zheng Q, Sun Z, Zhang L, Hui L, Cai X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| BioProject |
PRJNA820703 |
| |
| Submission date |
Apr 04, 2022 |
| Last update date |
Apr 04, 2023 |
| Contact name |
Lijian Hui |
| E-mail(s) |
huilab@sibcb.ac.cn
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| Organization name |
CEMCS, CAS
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| Department |
SIBCB
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| Lab |
Huilab
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| Street address |
yueyang road 320
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| City |
Shanghai |
| ZIP/Postal code |
200031 |
| Country |
China |
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| Platforms (1) |
| GPL22475 |
Illumina HiSeq 4000 (Sus scrofa) |
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| Samples (11)
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