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| Status |
Public on Jun 30, 2023 |
| Title |
Effects of CDK8/19 mediator kinase inhibition by didehydrocortistatin A (dCA) and 15w on gene expression in HEK293 cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA-Seq analysis was carried out to investigate the effects of selective CDK8/19 inhibitor didehydrocortistatin A (dCA) and 15w on gene expression in HEK293 cells (293-WT) or the CDK8/19 double-knockout (293-dKO) derivatives.
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| Overall design |
293-WT and 293-dKO cells were treated with 0.1% DMSO, 1 μM dCA or 1 μM 15w for 72 hours. Each treatment condition was done in biological triplicate.
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| Contributor(s) |
Chen M, Ji H, Roninson IB |
| Citation(s) |
37378433 |
| |
| Submission date |
Apr 13, 2022 |
| Last update date |
Aug 21, 2023 |
| Contact name |
HAO JI |
| E-mail(s) |
ji5@email.sc.edu
|
| Phone |
8037774689
|
| Organization name |
University of South Carolina
|
| Department |
College of Pharmacy
|
| Street address |
715 SUMTER ST CLS RM 109
|
| City |
COLUMBIA |
| State/province |
SC |
| ZIP/Postal code |
29208 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (18)
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| This SubSeries is part of SuperSeries: |
| GSE200754 |
Transcriptomic and Proteomic Effects of CDK8 and CDK19 Mediator Kinases |
|
| Relations |
| BioProject |
PRJNA826476 |
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