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| Status |
Public on Dec 28, 2022 |
| Title |
BCG-activation of lymphocytes for the generation of donor-independent innate anti-tumor NK and γδ T cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Other
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| Summary |
We performed scRNA-seq to PBMCs incubated with 2 different sub-strains of BCG during 7 days. We found that iBCG co-cultures potently stimulated the proliferation of TRDV2 gamma-delta T cells, while Oncotice did not have the ability to expand this subpopulation, and mainly stimulated NK and classical T cells.
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| Overall design |
mRNA profiles of paired PBMC samples from 3 healthy donors (treated with iBCG or Oncotice) were examined
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| Contributor(s) |
Esteso G, Felgueres MJ, García-Jiménez Á, Reyburn H, Puentes E, Murillo I, Rodríguez E, Valés-Gómez M, Vázquez de Luis E |
| Citation(s) |
36567803 |
| Submission date |
May 16, 2022 |
| Last update date |
Dec 28, 2022 |
| Contact name |
Enrique Vazquez de Luis |
| E-mail(s) |
quiquevzquez@gmail.com
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| Organization name |
CNIC
|
| Lab |
Genomics Unit
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| Street address |
Melchor Fernandez Almagro, 3
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| City |
Madrid |
| State/province |
Madrid |
| ZIP/Postal code |
28029 |
| Country |
Spain |
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| Platforms (1) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA838573 |
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