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Series GSE20474 Query DataSets for GSE20474
Status Public on Dec 31, 2010
Title aCGH study of lobular carcinoma in situ (LCIS) and invasive lobular carcinoma (ILC)
Organism Homo sapiens
Experiment type Genome variation profiling by array
Summary The identification of lobular caricnoma in situ (LCIS) in a patient's specimen confers and appreciable increased risk of development of future invasive mammary carcinoma. However the study of LCIS presents a challenge as it is usually only recognized in fixed specimens and no good in vivo or in vitro models currently exist. Recent advances in high throughput genomics have made possible comprehensive copy number analysis of lesions such as this. We have characterized LCIS on microdissected cases of archival patient samples using aCGH. We used 4 cases of LCIS with adjacent ILC.
 
Overall design Histological sections from 4 cases of LCIS and 4 cases of ILC microdissected, DNA extracted and subjected to whole genome amplification, and aCGH.
 
Contributor(s) Done SJ, Tran-Thanh D
Citation(s) 20658264
Submission date Feb 22, 2010
Last update date Jan 18, 2013
Contact name Susan Done
E-mail(s) sdone@uhnres.utoronto.ca
Organization name University Health Network
Street address 200 Elizabeth Street, 11E444
City Toronto
State/province ON
ZIP/Postal code M5G2C4
Country Canada
 
Platforms (1)
GPL10093 UHN Human 19K cDNA microarray
Samples (8)
GSM513685 lobular carcinoma in situ -1
GSM513686 lobular carcinoma in situ -2
GSM513687 lobular carcinoma in situ -3
Relations
BioProject PRJNA125023

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE20474_RAW.tar 19.4 Mb (http)(custom) TAR (of GPR)
Processed data included within Sample table

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