 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Jun 07, 2022 |
| Title |
Alterations in the gene expression profile in SKOV3 cells exposed to elaiophylin |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Elaiophylin was screened and identified as a novel autophagy inhibitor, with significant antitumor efficacy as a single agent. To explore the mechanisms by which elaiophylin kills cancer cells, NimbleGen 12x135K microarrays were used to find the gene expression changes in SKOV3 cells treated with elaiophylin for indicated time points.
The gene expression microarray data were also analyzed and described in our previous study. Zhao, X., Fang, Y., Yang, Y., Qin, Y., Wu, P., Wang, T., Lai, H., Meng, L., Wang, D., Zheng, Z., Lu, X., Zhang, H., Gao, Q., Zhou, J., & Ma, D. (2015). Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells. Autophagy, 11(10), 1849–1863 (PMID: 25893854).
|
| |
|
| Overall design |
Total RNA was extracted from SKOV3 cells exposed to 0.5 μM of elaiophylin for 0, 3, 6, or 12 h, and was subsequently subjected to microarray analysis. The Roche NimbleGen Human Genome 12×135K Array was used.
|
| |
|
| Contributor(s) |
Li G, Zhao X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jun 06, 2022 |
| Last update date |
Jun 09, 2022 |
| Contact name |
Guannan Li |
| E-mail(s) |
liguann@126.com
|
| Organization name |
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
|
| Department |
Department of Gynecological Oncology
|
| Lab |
Cancer Biology Research Center (Key Laboratory of the Ministry of Education)
|
| Street address |
1095 Jiefang Avenue
|
| City |
Wuhan |
| State/province |
Hubei |
| ZIP/Postal code |
430030 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL16025 |
NimbleGen Homo sapiens Expression Array [100718_HG18_opt_expr] |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA846276 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE205529_RAW.tar |
22.8 Mb |
(http)(custom) |
TAR (of PAIR) |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...