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| Status |
Public on Aug 01, 2022 |
| Title |
Single cell transcriptomics of the tumor immune microenvironment from checkpoint blockade-treated KPC tumors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Single cell transcriptomes of CD45+ cells from KPC tumor subcutaneous allografts, either treated with PD-1+CTLA-4 checkpoint blockade or treatment-naïve.
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| Overall design |
We isolated CD45+ cells from KPC tumors and performed 10X single-cell sequencing. KPC tumors were either treated with PD-1+CTLA-4 combination checkpoint blockade on days 6 and 9 post tumor challenge or treatment-naïve. Four tumors per experimental group were collected and sequenced.
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| Contributor(s) |
Du PP, Dubrot J, Lane-Reticker S, Kessler EA, Yates KB, Manguso RT |
| Citation(s) |
36151395 |
| |
| Submission date |
Jun 22, 2022 |
| Last update date |
Oct 12, 2022 |
| Contact name |
Peter P Du |
| Organization name |
Broad Institute
|
| Lab |
Manguso
|
| Street address |
415 Main St
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02142 |
| Country |
USA |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA851755 |
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