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Series GSE207397 Query DataSets for GSE207397
Status Public on Jun 20, 2023
Title ELL3 promotes stem cell native to primed transition through LINE-based enhancers [ChIP-Seq]
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Methylation profiling by high throughput sequencing
Summary Long interspersed nuclear elements-1 (LINE-1) are the clade of retrotransposons still possessing autonomous mobility in mammals. LINE-1 transcription contributed to global chromatin opening in mouse early embryos.Whether LINE-1 element plays a direct role in the local regulation of its nearby genes remains largely obscure.ELL3 occupies and represses the youngest LINE-1 family members L1Md_T and L1Md_Gf in naïve mouse ES cells.We found that the enhancer function of the evolutionally young LINE-1s, and suggests that ELL3 act as a key drivers of the naïve-primed transition through regulating the young LINE-1 based enhancers.
Overall design ChIpSeq
Contributor(s) Lin C, Liu X
Citation(s) 37591949
Submission date Jul 03, 2022
Last update date Sep 25, 2023
Contact name Xiaoxu Liu
Organization name Southeast University
Department Institute of Life Sciences
Lab the Key Laboratory of Developmental Genes and Human Disease
Street address 2 Sipailou
City Nanjing
State/province Jiangsu
ZIP/Postal code 210018
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (10)
GSM6285474 Chip-seq of Ell3
GSM6290592 ChIP-seq of Input
GSM6290593 ChIP-seq of H3K27ac in Ell3 KO
This SubSeries is part of SuperSeries:
GSE208227 ELL3 promotes stem cell native to primed transition through LINE-based enhancers
BioProject PRJNA855236

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE207397_RAW.tar 771.5 Mb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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