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Series GSE208013 Query DataSets for GSE208013
Status Public on Jul 15, 2022
Title Ameliorative effect of the oil components derived from sweet potato shochu on impaired short-term memory in mice after amyloid ß25-35 injection
Platform organism Mus musculus
Sample organism Mus
Experiment type Expression profiling by array
Summary In this study, we first analyzed the components of shochu oil and then investigated the effects of shochu oil on short-term memory, using a mouse model exhibiting spontaneous alternating behavior caused by the intracerebroventricular administration of Aß25-35. On the last day of the experiment, we examined gene expression in the mouse hippocampus using DNA microarrays. We confirmed the effect of the oil components derived from sweet potato shochu on impaired short-term memory in mice after amyloid ß25-35 injection.
Sweet potato shochu oil is a by-product of shochu production. We investigated the effects of shochu oil on short-term memory using a murine model of spontaneous alternating behavior induced by the intracerebroventricular administration of amyloid β25-35 (Aß25-35). Mice were orally administered shochu oil for 15 days. Experiments with a Y-maze model revealed that the Aß25-35 caused a significant decrease in spontaneous alternation behavior, and supplementation with shochu oil significantly improved this behavior. DNA microarray analysis revealed that the administration of shochu oil downregulated the expression of S100a9 and Ptgs2, which reportedly exacerbate amyloid β deposition in Alzheimer’s disease. The administration of shochu oil upregulated the expression of Dnaja1 and PP2A, which is typically downregulated in Alzheimer’s disease. These data suggest that shochu oil ameliorates symptoms of amyloid β lesions, as indicated by its effects on improving spontaneous alternation behavior and modulating the expressions of related genes.
Overall design The experiment was divided into three groups: the normal control group (NCO), the Aβ25-35 injected-control group (ACO), and the Aβ25-35 injected-shochu oil group (ASO). The average weights of each group (10 mice) were equal, assessed using a random computerized sampling method. The experimental procedure is shown in Fig. 1.
Contributor(s) Sho C, Kawano K, Hou D, Yoshimato M, Okuno H
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Submission date Jul 12, 2022
Last update date Jul 17, 2022
Contact name 超 章
Phone 07023999093
Organization name 霧島酒造株式会社
Street address 下川東4丁目28号1番
City 都城市
State/province 宮崎県
ZIP/Postal code 885-8588
Country Japan
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (3)
GSM6330083 NCO
GSM6330086 ACO
GSM6330088 ASO
BioProject PRJNA858019

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE208013_RAW.tar 12.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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