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| Status |
Public on Jan 30, 2023 |
| Title |
Effects of lactoferrin in PM2.5-induced nephrotoxicity |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Several epidemiological pieces of evidence on air pollution health effects have notably accelerated in recent years. They have described the relationship between PM2.5 (ambient fine particulate matter of <2.5 μm in diameter) and kidney diseases. Previous research has shown that lactoferrin showed renoprotective effects against some kidney diseases. In the current study, we analyzed the transcriptional profiles of PM2.5 and lactoferrin using RNA sequencing (RNA-seq) and identified the key signaling pathway in the human kidney proximal tubular epithelial cell line (HK-2 cells).
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| Overall design |
RNA-seq of human kidney proximal tubular epithelial cell line (HK-2 cells) treated with PM2.5 and lactoferrin. Cells were pretreated with lactoferrin (40 mg/ml) for 6 h and then treated with PM2.5 (1 mg/ml) for 18 h.
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| Web link |
https://pubmed.ncbi.nlm.nih.gov/36528199/
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| Contributor(s) |
Chiu YJ, Liu WC, Lee YH, Chiu HW |
| Citation(s) |
36528199 |
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| Submission date |
Jul 16, 2022 |
| Last update date |
May 01, 2023 |
| Contact name |
Yung-Li Wang |
| Organization name |
Graduate Institute of Clinical Medicine, Taipei Medical University
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| Street address |
250 Wu-Hsing Street
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| City |
Taipei |
| ZIP/Postal code |
110 |
| Country |
Taiwan |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (9)
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| GSM6341147 |
HK-2 cells, Lactoferrin and PM2.5, t24h, control sample, rep1 |
| GSM6341148 |
HK-2 cells, Lactoferrin and PM2.5, t24h, control sample, rep2 |
| GSM6341149 |
HK-2 cells, Lactoferrin and PM2.5, t24h, control sample, rep3 |
| GSM6341150 |
HK-2 cells, PM2.5, t24h, rep1 |
| GSM6341151 |
HK-2 cells, PM2.5, t24h, rep2 |
| GSM6341152 |
HK-2 cells, PM2.5, t24h, rep3 |
| GSM6341153 |
HK-2 cells, Lactoferrin and PM2.5, t24h, rep1 |
| GSM6341154 |
HK-2 cells, Lactoferrin and PM2.5, t24h, rep2 |
| GSM6341155 |
HK-2 cells, Lactoferrin and PM2.5, t24h, rep3 |
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| Relations |
| BioProject |
PRJNA859375 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE208331_RAW.tar |
3.1 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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