|
| Status |
Public on Jul 20, 2022 |
| Title |
Molecular Epidemiology of Enterobacterales Resistant to Antibiotics of Last Resort in Pregnant Women in Labour at a Tertiary Hospital |
| Organisms |
Enterobacter cloacae; Klebsiella pneumoniae; Enterobacter roggenkampii |
| Experiment type |
Methylation profiling by high throughput sequencing
Other
|
| Summary |
This study aims to determine the epidemiology of Enterobacteriaceae resistant to antibiotics of last resort in pregnant women in labour at a tertiary hospital, Pretoria, South Africa. Rectal swabs shall be used to screen for colonisation with CRE and colistin-resistant Enterobacteriales in pregnant women during labour. Carbapenem and colistin-resistant Enterobacterales can cause the following infections: bacteraemia; nosocomial pneumonia; urinary tract infections, and intra-abdominal infections. Due to limited treatment options, infections caused by these multidrug-resistant organisms are associated with a mortality rate of 40-50%. Screening for colonisation of carbapenem-resistant Enterobacteriaceae (CRE) and colistin-resistant Enterobacteriaceae will help implement infection and prevention measures to limit the spread of these multidrug-resistant organisms.
|
| |
|
| Overall design |
Genomic and epigenomic characterisation of carbapenem- and colistin-resistant Enterobacter spp. & K. pneumoniae
|
| |
|
| Contributor(s) |
Ntsoane VR, Mbelle NM, Sekyere JO |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| BioProject |
PRJNA769740 |
| |
| Submission date |
Jul 19, 2022 |
| Last update date |
Jul 23, 2022 |
| Contact name |
John Osei Sekyere |
| E-mail(s) |
jod14139@gmail.com
|
| Phone |
0123192251
|
| Organization name |
University of Pretoria
|
| Department |
Department of Medical Microbiology
|
| Lab |
Molecular Microbiology
|
| Street address |
05 Bopheloweg Off Dr. Savage Road
|
| City |
Pretoria |
| State/province |
Gauteng |
| ZIP/Postal code |
0084 |
| Country |
South Africa |
| |
|
| Platforms (3) |
| GPL27625 |
Sequel (Klebsiella pneumoniae) |
| GPL32492 |
Sequel (Enterobacter cloacae) |
| GPL32493 |
Sequel (Enterobacter roggenkampii) |
|
| Samples (5)
|
|
Less...
More...