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| Status |
Public on Sep 11, 2023 |
| Title |
Characterization of Global DNA Methylome in Mild Cognitive Impairment and Alzheimer's Disease |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
Genome-wide profiling of DNA methylation in blood leukocytes from Chinese patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). The Illumina Infinium MethylationEPIC BeadChip array (850K chip) was used to detect DNA methylation profiles throughout approximately 850,000 CpG sites in peripheral blood white cells of MCI- and AD-affected Chinese patients, as well as cognitively healthy controls. All samples included 20 Chinese patients with MCI, 20 Chinese patients with AD, and 20 cognitively healthy controls.
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| Overall design |
Genomic DNA was converted by bisulphite, and subsequently hybridised to the Illumina Infinium MethylationEPIC BeadChip.
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| Contributor(s) |
Wu S, Yang F, Chao S, Li H, Yu L, He L, Li X, Sun L, Qin S |
| Citation(s) |
37388929 |
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| Submission date |
Jul 20, 2022 |
| Last update date |
Sep 12, 2023 |
| Contact name |
Shan Chao |
| E-mail(s) |
bicyclecad@gmail.com
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| Organization name |
Shanghai Decoding Research Institute
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| Street address |
Huashan Rd, No. 2018
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| City |
Shanghai |
| ZIP/Postal code |
200030 |
| Country |
China |
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| Platforms (1) |
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| Samples (60)
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| Relations |
| BioProject |
PRJNA860378 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE208623_Norm_beta.csv.gz |
346.3 Mb |
(ftp)(http) |
CSV |
| GSE208623_RAW.tar |
991.3 Mb |
(http)(custom) |
TAR (of IDAT) |
| Processed data included within Sample table |
| Processed data are available on Series record |
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