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| Status |
Public on Feb 01, 2011 |
| Title |
Alteration of gene expression in mammary gland tissue of dairy cows in response to dietary unsaturated fatty acids |
| Organism |
Bos taurus |
| Experiment type |
Expression profiling by array
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| Summary |
The aim of this study was to determine the effects of unprotected dietary unsaturated fatty acids (UFA) from different plant oils on gene expression in the mammary gland of grazing dairy cows.
Milk composition and gene expression in the mammary gland tissue were evaluated in grazing dairy cows supplemented with different unsaturated fatty acids (UFA). The UFA supplementation improves the health and nutrition quality aspects of dairy milk, but also affects the gene networks expression signature associated with cellular growth and proliferation, cell-death, signalling, nutrient metabolism, and immune response, and in turn, the mammary gland integrity and health.
SUBMITTER_CITATION: Mach, N., A. A. A. Jacobs, L. Kruijt, J. Van Baal, and M. A. Smits. 2011. Alteration of gene expression in mammary gland tissue of dairy cows in response to dietary unsaturated fatty acids. Animal.DOI:10.1017/S1751731111000103
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| Overall design |
A total of 28 Holstein-Friesian dairy cows in mid-lactation were blocked according to parity (2.4 ± 0.63 years), days in milk (DIM; 153 ± 32.8 days), milk yield (25.7 ± 3.08 kg/d) and fat content (4.3 ± 0.12%). Cows were then randomly assigned to four UFA-sources based on rapeseed, soybean, linseed or a mixture of the three oils for 23 days (Period I) after which, all 28 cows were switched to a control diet for an additional 28 days (Period II). On the last day of both periods, mammary gland biopsies were taken to study genome-wide differences in lipid metabolism gene expression.
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| Contributor(s) |
Mach N, Jacobs AA, Kruijt L, van Baal J, Smits M |
| Citation(s) |
22440174 |
| Submission date |
Mar 16, 2010 |
| Last update date |
Mar 27, 2023 |
| Contact name |
Nuria Mach |
| E-mail(s) |
nuria.mach@inra.jouy.fr
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| Organization name |
INRA
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| Department |
Animal Genetics and Integrative Biology (GABI)
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| Lab |
Laboratory of Animal Genetics
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| Street address |
Rue de Vilvert
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| City |
Jouy-en-Josas |
| State/province |
Ile de France |
| ZIP/Postal code |
78350 |
| Country |
France |
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| Platforms (1) |
| GPL10186 |
[Bovine] Affymetrix Bovine Genome Array [CDF: Brainarray Version 11.0.1, Bovine_Bt_REFSEQ] |
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| Samples (55)
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| Relations |
| BioProject |
PRJNA124449 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE20909_RAW.tar |
105.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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