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Status |
Public on May 17, 2024 |
Title |
Effect of neonatal right ventricular pressure overload on gene expression and regions of open chromatin during postnatal heart development |
Organism |
Rattus norvegicus |
Experiment type |
Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing
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Summary |
To investigate the effect of pressure overload (PO) during postnatal right ventricular (RV) development, we established the RV PO model by conducting pulmonary artery banding (PAB) surgery on neonatal Sprague-Dawley (SD) rats. We then performed gene expression and chromatin openness profiling analysis using data obtained from RNA-seq and ATAC-seq of RV free walls from PO and sham-operated rats at postnatal day 21 (P21).
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Overall design |
Comparative gene expression and chromatin openness profiling analysis of RNA-seq and ATAC-seq data for right ventricular free wall myocardium in pressure overload and sham-operated Sprague-Dawley (SD) rats on postnatal day21.
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Contributor(s) |
Hu Y, Li D, Ye L, Li F |
Citation(s) |
38666846 |
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Submission date |
Aug 01, 2022 |
Last update date |
May 18, 2024 |
Contact name |
Yuqing Hu |
E-mail(s) |
christy497@outlook.com
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Organization name |
Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine
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Street address |
1678 Dongfang Road, Pudong New District, Shanghai
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City |
Shanghai |
ZIP/Postal code |
200127 |
Country |
China |
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Platforms (1) |
GPL25947 |
Illumina NovaSeq 6000 (Rattus norvegicus) |
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Samples (12)
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GSM6423045 |
RV free wall, sham-operated, P21, RNA-seq, rep1 |
GSM6423046 |
RV free wall, sham-operated, P21, RNA-seq, rep2 |
GSM6423047 |
RV free wall, sham-operated, P21, RNA-seq, rep3 |
GSM6423048 |
RV free wall, PAB-operated, P21, RNA-seq, rep1 |
GSM6423049 |
RV free wall, PAB-operated, P21, RNA-seq, rep2 |
GSM6423050 |
RV free wall, PAB-operated, P21, RNA-seq, rep3 |
GSM6423051 |
RV free wall, sham-operated, P21, ATAC-seq, rep1 |
GSM6423052 |
RV free wall, sham-operated, P21, ATAC-seq, rep2 |
GSM6423053 |
RV free wall, sham-operated, P21, ATAC-seq, rep3 |
GSM6423054 |
RV free wall, PAB-operated, P21, ATAC-seq, rep1 |
GSM6423055 |
RV free wall, PAB-operated, P21, ATAC-seq, rep2 |
GSM6423056 |
RV free wall, PAB-operated, P21, ATAC-seq, rep3 |
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Relations |
BioProject |
PRJNA864632 |
Supplementary file |
Size |
Download |
File type/resource |
GSE210180_RAW.tar |
13.0 Mb |
(http)(custom) |
TAR (of TXT) |
GSE210180_gene_fpkm.txt.gz |
2.0 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
Raw data are available in SRA |
Processed data provided as supplementary file |
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