|
| Status |
Public on Dec 06, 2023 |
| Title |
Metabolic stress induces gene reprograming in ALL cells [RNA-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
To identify genes transcriptionally regulated under energy/metabolic stress, we treated CCRF-CEM/HA-AMPKa2 cells with Glucose deprivation condition for 24 hours, and examined their RNA profile using RNA-Seq. More than 3000 genes was altered (Fold Change > 1.5 or < -1.5, q value < 0.05) under energy/metabolic stress (glucose deprivation) vs. control, with approximately 60-70% genes exhibiting downregulation, whereas the remainder show upregulation. Note: sample headers in data_matrix_ctrl_no_glucose.txt, CTRL_7: Ctrl rep1 sample count number; CTRL_8: Ctrl rep2 count number; ONG_9: No glucose rep1 count number; ONG_10: No glucose rep2 count number;
|
| |
|
| Overall design |
RNA-seq in CCRF-CEM/HA-AMPKa2 cells treated with vehicle or Glucose deprivation condition.
|
| |
|
| Contributor(s) |
Sun G, Leclerc GJ, Barredo JC |
| Citation(s) |
37682252 |
| |
| Submission date |
Aug 01, 2022 |
| Last update date |
Dec 06, 2023 |
| Contact name |
Julio C Barredo |
| Organization name |
University of Miami
|
| Street address |
1580 NW 10th ave room
|
| City |
MIAMI |
| State/province |
Florida |
| ZIP/Postal code |
33136 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (4)
|
|
| This SubSeries is part of SuperSeries: |
| GSE210214 |
AMPK directly regulate a subset of genes expression in ALL cells |
|
| Relations |
| BioProject |
PRJNA864779 |
Less...
More...