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| Status |
Public on Aug 12, 2023 |
| Title |
Placental ischemia disrupts DNA methylation patterns of distal regulatory regions in rat |
| Organisms |
Homo sapiens; Rattus norvegicus |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
We carry out whole-genome bisulfite sequencing (WGBS) of rat placental DNA to investigate epigenome-wide alterations in a reduced uterine perfusion pressure (RUPP) PE model.
The Hidden Markov Model (HMM) was applied to identify functional epigenetic structures including partially methylated domains (PMDs), low methylated regions (LMRs) and unmethylated regions (UMRs).
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| Overall design |
Whole genome bisulfite sequencing (WGBS) of six placenta samples, including three reduced uterine perfusion pressure (RUPP) rat placenta samples and three control placenta samples
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| Contributor(s) |
Zhao X, Zheng X, Lian Y, Zhou Q |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Aug 14, 2022 |
| Last update date |
Aug 12, 2023 |
| Contact name |
Xiaoguo Zheng |
| E-mail(s) |
zxg@sagc.org.cn
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| Phone |
+86-15021928432
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| Organization name |
Shanghai Jiaotong University
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| Street address |
145 Guangyuan Road
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| City |
Shanghai |
| ZIP/Postal code |
200030 |
| Country |
China |
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| Platforms (2) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
| GPL24688 |
HiSeq X Ten (Rattus norvegicus) |
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| Samples (7)
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| Relations |
| BioProject |
PRJNA869459 |
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