|
| Status |
Public on Jul 04, 2024 |
| Title |
Microglia aging advances through intermediate states that drive inflammatory activation and cognitive decline |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
TGFB-signaling is important for the establishment of microglia homeostasis; however, it's role in aging has remained vague. We found that Tgfb1 and TGFB signaling is altered during hippocampal microglia aging. To investigate the effects that microglia-derived Tgfb1 has on microglia aging, we performed scRNA-Seq on Cd11b+ cells from the hippocampus of mature mice where Tgfb1 had been ablated from Cx3cr1 cells post-maturity.
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| |
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| Overall design |
scRNA-Seq of Cx3cr1-CreERT Tgfb1 cKO Cd11b+ cells from mature mouse hippocampi
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| |
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| Contributor(s) |
Shea J, Villeda S |
| Citation missing |
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| |
| Submission date |
Aug 16, 2022 |
| Last update date |
Jul 04, 2024 |
| Contact name |
Jeremy Michael Shea |
| Organization name |
University of California, San Francisco
|
| Department |
Anatomy
|
| Lab |
Villeda
|
| Street address |
513 Parnassus Avenue
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94143 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (6)
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|
| Relations |
| BioProject |
PRJNA869921 |
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