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| Status |
Public on Sep 20, 2022 |
| Title |
Fetal genetic findings for fetal growth restriction without structural malformations at a territory referral center: 10-year experience |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
SNP genotyping by SNP array
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| Summary |
We retrospectively reviewed 488 fetuses who diagnosed with FGR and without structural malformation during a 10-year period. A total of 19 (3.9%) cases of chromosomal anomalies were detected, including 11 cases of numerical abnormalities, 5 of structural abnormalities, and 3 of mosaicism. We classified the cohort into cases diagnosed at ≤24, 25-28, 29-32, and > 32 weeks of gestation according to the onset gestations; isolated FGR, FGR with soft markers, and FGR with nonstructural anomalies according to different ultrasound findings; high and low-risk maternal serum screening (MSS) groups based on the MSS results. The results suggested that abnormal karyotypes were more frequently detected in cases diagnosed at ≤24 weeks (7.2%), cases with soft markers (5.2%), and cases with high-risk MSS (7.5%) than in other groups within each classification. Among cases with normal karyotype, additional 4.2% of clinically relevant aberrations were detected by SNP array. The incremental yields in cases diagnosed at ≤24 weeks (6.5%), cases with soft markers (9.5%), and cases with high-risk MSS (12.0%) were higher than those in other groups within each classification. We concluded that fetal chromosomal aberration is an important etiology for FGR without structural malformation, and plays an important role in pregnancies decision-making. SNP array improves the detection of genetic anomalies especially in fetuses diagnosed at ≤24 weeks, fetuses with soft makers, and fetuses with high risk of MSS.
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| Overall design |
We retrospectively reviewed 488 fetuses who diagnosed with FGR and without structural malformation. Conventional karyotyping was performed on all subjects, and SNP array was performed on 272 of them. The cohort was classified into groups diagnosed at ≤24, 25-28, 29-32, and > 32 weeks of gestation. According to the ultrasonography, they were grouped into isolated FGR, FGR with soft markers, and FGR with nonstructural anomalies. Based on the maternal serum screening (MSS), they were categorized into high-risk and low-risk MSS groups. The rates of abnormal karyotypes and incremental yield of clinically significant aberrations detected by SNP array were compared among groups in different classifications.
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Submitter states: "Some CEL files were lost because of the damage of hard disc."
This submission includes 10 CEL files only
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| Contributor(s) |
Wu X, Xu L |
| Citation(s) |
36703098 |
| Submission date |
Aug 18, 2022 |
| Last update date |
Feb 08, 2023 |
| Contact name |
Xiaoqing Wu |
| E-mail(s) |
wuxiaoqing013@126.com
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| Phone |
+8618650789891
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| Organization name |
Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University
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| Street address |
18 daoshan road, Gulou district
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| City |
Fuzhou |
| ZIP/Postal code |
350001 |
| Country |
China |
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| Platforms (1) |
| GPL18637 |
[CytoScan750K_Array] Affymetrix CytoScan 750K Array |
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| Samples (31)
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| Relations |
| BioProject |
PRJNA870933 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE211577_RAW.tar |
1.0 Gb |
(http)(custom) |
TAR (of CEL, CYCHP) |
| Processed data provided as supplementary file |
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