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| Status |
Public on Sep 20, 2023 |
| Title |
CFL1-induced super enhancer RNA m6A modification promotes local chromatin accessibility and oncogenes transcription in pancreatic cancer [m6A-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
Herein, we describe the landscape of m6A on super enhancer RNAs (seRNAs) in pancreatic ductal adenocarcinoma (PDAC) and demonstrate a regulatory axis involving m6A-seRNAs, H3K4me3 modification, chromatin accessibility and oncogenic transcription.
our study has revealed the CFL1-YTHDC2-MLL1 epigenetic regulatory axis plays critical roles of dynamic m6A deposition in seRNAs and local chromatin state, which may be a novel oncogenic mechanism in PDAC and shed light on the crosstalk between epitranscriptome and epigenome.
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| Overall design |
m6A-seq data of PANC-1
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| Contributor(s) |
Li R, Zhao H, Huang X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Aug 18, 2022 |
| Last update date |
Sep 20, 2023 |
| Contact name |
Rui Li |
| E-mail(s) |
lirui@sysucc.org.cn
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| Organization name |
Sun Yat-sen University Cancer Center
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| Street address |
651 Dongfeng East Road
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| City |
Guangzhou |
| ZIP/Postal code |
510060 |
| Country |
China |
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| Platforms (1) |
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| Samples (32)
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| GSM6481162 |
KO CFL1_2, input |
| GSM6481163 |
KO METTL3_1, ip |
| GSM6481164 |
KO METTL3_2, ip |
| GSM6481165 |
KO METTL3_1, input |
| GSM6481166 |
KO METTL3_2, input |
| GSM6481167 |
Control_1, ip |
| GSM6481168 |
Control_2, ip |
| GSM6481169 |
Control_1, input |
| GSM6481170 |
Control_2, input |
| GSM7498818 |
KO CFL1_1, ip [nuclear RNA] |
| GSM7498819 |
KO CFL1_2, ip [nuclear RNA] |
| GSM7498820 |
KO CFL1_1, input [nuclear RNA] |
| GSM7498821 |
KO CFL1_2, input [nuclear RNA] |
| GSM7498822 |
KO METTL3_1, ip [nuclear RNA] |
| GSM7498823 |
KO METTL3_2, ip [nuclear RNA] |
| GSM7498824 |
KO METTL3_1, input [nuclear RNA] |
| GSM7498825 |
KO METTL3_2, input [nuclear RNA] |
| GSM7498826 |
Control_1, ip [nuclear RNA] |
| GSM7498827 |
Control_2, ip [nuclear RNA] |
| GSM7498828 |
Control_1, input [nuclear RNA] |
| GSM7498829 |
Control_2, input [nuclear RNA] |
| GSM7498830 |
addDrug_1, ip |
| GSM7498831 |
addDrug_2, ip |
| GSM7498832 |
addDrug_1, input |
| GSM7498833 |
addDrug_2, input |
| GSM7498834 |
notaddDrug_1, ip |
| GSM7498835 |
notaddDrug_2, ip |
| GSM7498836 |
notaddDrug_1, input |
| GSM7498837 |
notaddDrug_2, input |
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| This SubSeries is part of SuperSeries: |
| GSE211589 |
CFL1-induced super enhancer RNA m6A modification promotes local chromatin accessibility and oncogenes transcription in pancreatic cancer |
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| Relations |
| BioProject |
PRJNA870953 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE211588_AddDrug12_IPtoInput.bw |
36.4 Mb |
(ftp)(http) |
BW |
| GSE211588_NotaddDrug12_IPtoInput.bw |
36.2 Mb |
(ftp)(http) |
BW |
| GSE211588_control12_merge.narrowPeak.gz |
4.1 Mb |
(ftp)(http) |
NARROWPEAK |
| GSE211588_koCFL1_12_merge.narrowPeak.gz |
3.4 Mb |
(ftp)(http) |
NARROWPEAK |
| GSE211588_koMETTL3_12_merge.narrowPeak.gz |
3.2 Mb |
(ftp)(http) |
NARROWPEAK |
| GSE211588_m6Aseq_control12.bw |
98.4 Mb |
(ftp)(http) |
BW |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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