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| Status |
Public on Jan 01, 2023 |
| Title |
Single cell analysis on the HIV-infected kidney cells |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
HIV-vpr expression was mainly detected in tubule cells after infection. By comparing the HIV-infected and wild type kidney cells on single cell level, a strong shift was observed in the PT S3 segment cell population. Transcription factor analysis revealed Trp53 playing important regulation role in HIV infected cells.
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| Overall design |
VPR;Pax8-rtTa mice were fed DOX grain-based rodent diet at 7 week of age and continued for 11 weeks induction until mice were euthanized. 3 VPR;Pax8-rtTa mice and 2 Wild type mice were sequenced.
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| |
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| Contributor(s) |
Fu J, Sun Z, Chen Y |
| Citation(s) |
36565808 |
| |
| Submission date |
Aug 29, 2022 |
| Last update date |
Apr 13, 2023 |
| Contact name |
Zeguo Sun |
| E-mail(s) |
zeguo.sun@mssm.edu
|
| Phone |
6466427380
|
| Organization name |
Ichan School of Medicine at Mount Sinai
|
| Street address |
1468 Madison Avenue
|
| City |
New York |
| ZIP/Postal code |
10029 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (5)
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| Relations |
| BioProject |
PRJNA874685 |
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