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Series GSE212291 Query DataSets for GSE212291
Status Public on Mar 04, 2024
Title Analysis of exosomal miRNAs in MCF7 cells regulated by LSD1
Organism Homo sapiens
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary Lysine specific demethylase 1 (LSD1) is an important histone demethylase that mediates metastasis in luminal breast cancer. Exosomes play a major role in cell-to-cell communication. Thus, the characterization of miRNAs of exosome in MCF7 cells regulated by LSD1 is imperative in clarifying intercellular signaling.
 
Overall design miRNA-seq in exosomes isolated from scrambled control siRNAs transfected MCF7 cells (NC), LSD1-specific siRNAs transfected MCF7 (KD), MCF7 cells transfected with LSD1-specific siRNAs and LSD1 rescue plasmid (RE). Each cell type have 3 biological replicates.
 
Contributor(s) Liu Z, Hu X
Citation(s) 38448424
Submission date Aug 30, 2022
Last update date Mar 13, 2024
Contact name Xin Hu
E-mail(s) huxin@jlu.edu.cn
Organization name Jilin university
Street address 2699 Qianjin road,china
City Chang Chun
ZIP/Postal code 130012
Country China
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (9)
GSM6523438 EXO-NC1
GSM6523439 EXO-NC2
GSM6523440 EXO-NC3
Relations
BioProject PRJNA874891

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE212291_Reads_count_miRNA.xlsx 146.5 Kb (ftp)(http) XLSX
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Raw data are available in SRA
Processed data are available on Series record

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