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GEO help: Mouse over screen elements for information. |
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Status |
Public on Jul 28, 2024 |
Title |
Deletion of a state-specific PD-1 enhancer modulates exhausted T cell fate and function |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing
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Summary |
This SuperSeries is composed of the SubSeries listed below.
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Overall design |
Refer to individual Series
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Web link |
https://doi.org/10.1038/s41590-024-01961-3
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Citation(s) |
39289557 |
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Submission date |
Sep 01, 2022 |
Last update date |
Oct 01, 2024 |
Contact name |
Amy Huang |
Organization name |
Harvard Medical School
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Department |
Immunology
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Lab |
Sharpe
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Street address |
25 Shattuck St
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City |
Boston |
State/province |
MA |
ZIP/Postal code |
02115 |
Country |
USA |
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Platforms (2) |
GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
GPL32159 |
NextSeq 1000 (Mus musculus) |
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Samples (34)
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GSM6529081 |
EnhDel, CD8+ T cells, 2 |
GSM6529082 |
WT, CD8+ T cells, 1 |
GSM6529083 |
WT, CD8+ T cells, 2 |
GSM6533800 |
Pdcd1 EnhDel terminally exhausted CD8+ T cells, replicate 1, ATACseq |
GSM6533801 |
Pdcd1 EnhDel progenitor exhausted CD8+ T cells, replicate 1, ATACseq |
GSM6533802 |
Pdcd1 EnhDel terminally exhausted CD8+ T cells, replicate 2, ATACseq |
GSM6533803 |
Pdcd1 EnhDel progenitor exhausted CD8+ T cells, replicate 2, ATACseq |
GSM6533804 |
PD-1 KO terminally exhausted CD8+ T cells, repilcate 1, ATACseq |
GSM6533805 |
PD-1 KO progenitor exhausted CD8+ T cells, replicate 1, ATACseq |
GSM6533806 |
PD-1 KO terminally exhausted CD8+ T cells, replicate 2, ATACseq |
GSM6533807 |
PD-1 KO progenitor exhausted CD8+ T cells, replicate 2, ATACseq |
GSM6533808 |
Wild type terminally exhausted CD8+ T cells, replicate 1, ATACseq |
GSM6533809 |
Wild type progenitor exhausted CD8+ T cells, replicate 1, ATACseq |
GSM6533810 |
Wild type terminally exhausted CD8+ T cells, replicate 2, ATACseq |
GSM6533811 |
Wild type progenitor exhausted CD8+ T cells, replicate 2, ATACseq |
GSM8322427 |
WT CD8+ T cells, Day 9, Slamf6-TIM3+CX3CR1-, sample 3 |
GSM8322428 |
EnhDel CD8+ T cells, Day 9, Slamf6-TIM3+CX3CR1-, sample 6 |
GSM8322429 |
EnhDel CD8+ T cells, Day 9, Slamf6-TIM3+CX3CR1-, sample 12 |
GSM8322430 |
EnhDel CD8+ T cells, Day 9, Slamf6-TIM3+CX3CR1-, sample 18 |
GSM8322431 |
WT CD8+ T cells, Day 9, Slamf6-TIM3+CX3CR1-, sample 15 |
GSM8322432 |
WT CD8+ T cells, Day 9, Slamf6-TIM3+CX3CR1-, sample 21 |
GSM8322433 |
EnhDel CD8+ T cells, Day 9, Slamf6-TIM3+CX3CR1-, sample 25 |
GSM8322434 |
WT CD8+ T cells, Day 9, Slamf6-TIM3+CX3CR1-, sample 9 |
GSM8322435 |
EnhDel CD8+ T cells, Day 9, Slamf6+TIM3-, sample 4 |
GSM8322436 |
WT CD8+ T cells, Day 9, Slamf6+TIM3-, sample 1 |
GSM8322437 |
WT CD8+ T cells, Day 9, Slamf6+TIM3-, sample 7 |
GSM8322438 |
EnhDel CD8+ T cells, Day 9, Slamf6+TIM3-, sample 10 |
GSM8322439 |
EnhDel CD8+ T cells, Day 9, Slamf6+TIM3-, sample 16 |
GSM8322440 |
WT CD8+ T cells, Day 9, Slamf6+TIM3-, sample 13 |
GSM8322441 |
WT CD8+ T cells, Day 9, Slamf6+TIM3-, sample 19 |
GSM8322442 |
EnhDel CD8+ T cells, Day 9, Slamf6+TIM3-, sample 22 |
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This SuperSeries is composed of the following SubSeries: |
GSE212379 |
Deletion of a state-specific PD-1 enhancer modulates exhausted T cell fate and function [scRNA-seq] |
GSE212506 |
Deletion of a state-specific PD-1 enhancer modulates exhausted T cell fate and function [ATAC-seq] |
GSE269580 |
Deletion of a state-specific PD-1 enhancer modulates exhausted T cell fate and function [RNA-Seq] |
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Relations |
BioProject |
PRJNA875652 |
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