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| Status |
Public on Sep 04, 2022 |
| Title |
Identifying Altered Developmental Pathways in Induced Pluripotent Stem Cell-Derived Neural Stem Cells From a Patients with Globoid Cell Leukodystrophy Using Transcriptome Profiling |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
we identified gene-expression changes in induced pluripotent stem cells (iPSCs) and iPSC-derived neural stem cells (NSCs) from a patients with GLD (K-iPSCs/NSCs) and normal control (AF-iPSCs/NSCs), in order to investigate the potential mechanism underlying GLD pathogenesis. We identified 194 (K-iPSCs vs. AF-iPSCs) and 702 (K-NSCs vs. AF-NSCs) significantly dysregulated mRNAs when comparing the indicated groups. We also identified dozens of Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway terms that were enriched for the differentially expressed genes.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for induced pluripotent stem cells (iPSCs) and iPSC-derived neural stem cells (NSCs) from a patients with GLD
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| Contributor(s) |
Lv Y, Wang W |
| Citation(s) |
37076788 |
| |
| Submission date |
Sep 01, 2022 |
| Last update date |
May 12, 2023 |
| Contact name |
yafeng lv |
| E-mail(s) |
lvyafeng@ctgu.edu.cn
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| Organization name |
China Three Gorges University
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| Street address |
No. 8, Daxue Road, Xiling District, Yichang City
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| City |
yichang |
| ZIP/Postal code |
443002 |
| Country |
China |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA875679 |
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