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| Status |
Public on Oct 10, 2022 |
| Title |
Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
This study reports clinical, genetic, epigenetic, gene expression, and cellular features distinguishing meningioma DNA methylation subgroups within meningioma DNA methylation groups. We present these data in the context of molecular and clinical models predicting postoperative outcomes across 565 meningiomas with comprehensive clinical follow-up from independent discovery and validation institutions. By discovering meningioma DNA methylation subgroups within meningioma DNA methylation groups, we provide an opportunity to resolve inconsistencies in the recent literature. In doing so, our study establishes an architecture that unifies opposing biological theories for the most common primary intracranial tumor
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| Overall design |
RNA-sequencing data is used to examine transcriptional signatures of meningioma subgroups in the context of methylation classification.
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| |
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| Contributor(s) |
Choudhury A, Raleigh D, Chen WC |
| Citation(s) |
36227281, 38509407 |
| |
| Submission date |
Sep 04, 2022 |
| Last update date |
Apr 02, 2024 |
| Contact name |
William Chen |
| Organization name |
UCSF
|
| Street address |
1450 3rd Street, HD 402
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94158 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (302)
|
| GSM6542805 |
Human meningoma, QM6 |
| GSM6542806 |
Human meningoma, QM7 |
| GSM6542807 |
Human meningoma, QM8 |
| GSM6542808 |
Human meningoma, QM9 |
| GSM6542809 |
Human meningoma, QM11 |
| GSM6542810 |
Human meningoma, QM12 |
| GSM6542811 |
Human meningoma, QM13 |
| GSM6542812 |
Human meningoma, QM14 |
| GSM6542813 |
Human meningoma, QM15 |
| GSM6542814 |
Human meningoma, QM16 |
| GSM6542815 |
Human meningoma, QM17 |
| GSM6542816 |
Human meningoma, QM19 |
| GSM6542817 |
Human meningoma, QM20 |
| GSM6542818 |
Human meningoma, QM21 |
| GSM6542819 |
Human meningoma, QM23 |
| GSM6542820 |
Human meningoma, QM24 |
| GSM6542821 |
Human meningoma, QM25 |
| GSM6542822 |
Human meningoma, QM26 |
| GSM6542823 |
Human meningoma, QM27 |
| GSM6542824 |
Human meningoma, QM28 |
| GSM6542825 |
Human meningoma, QM29 |
| GSM6542826 |
Human meningoma, QM30 |
| GSM6542827 |
Human meningoma, QM32 |
| GSM6542828 |
Human meningoma, QM33 |
| GSM6542829 |
Human meningoma, QM34 |
| GSM6542830 |
Human meningoma, QM36 |
| GSM6542831 |
Human meningoma, QM39 |
| GSM6542832 |
Human meningoma, QM40 |
| GSM6542833 |
Human meningoma, QM42 |
| GSM6542834 |
Human meningoma, QM46 |
| GSM6542835 |
Human meningoma, QM47 |
| GSM6542836 |
Human meningoma, QM48 |
| GSM6542837 |
Human meningoma, QM49 |
| GSM6542838 |
Human meningoma, QM50 |
| GSM6542839 |
Human meningoma, QM51 |
| GSM6542840 |
Human meningoma, QM52 |
| GSM6542841 |
Human meningoma, QM53 |
| GSM6542842 |
Human meningoma, QM59 |
| GSM6542843 |
Human meningoma, QM60 |
| GSM6542844 |
Human meningoma, QM62 |
| GSM6542845 |
Human meningoma, QM64 |
| GSM6542846 |
Human meningoma, QM65 |
| GSM6542847 |
Human meningoma, QM66 |
| GSM6542848 |
Human meningoma, QM67 |
| GSM6542849 |
Human meningoma, QM69 |
| GSM6542850 |
Human meningoma, QM71 |
| GSM6542851 |
Human meningoma, QM76 |
| GSM6542852 |
Human meningoma, QM77 |
| GSM6542853 |
Human meningoma, QM78 |
| GSM6542854 |
Human meningoma, QM79 |
| GSM6542855 |
Human meningoma, QM80 |
| GSM6542856 |
Human meningoma, QM83 |
| GSM6542857 |
Human meningoma, QM86 |
| GSM6542858 |
Human meningoma, QM87 |
| GSM6542859 |
Human meningoma, QM90 |
| GSM6542860 |
Human meningoma, QM91 |
| GSM6542861 |
Human meningoma, QM92 |
| GSM6542862 |
Human meningoma, QM93 |
| GSM6542863 |
Human meningoma, QM94 |
| GSM6542864 |
Human meningoma, QM95 |
| GSM6542865 |
Human meningoma, QM96 |
| GSM6542866 |
Human meningoma, QM98 |
| GSM6542867 |
Human meningoma, QM100 |
| GSM6542868 |
Human meningoma, QM102 |
| GSM6542869 |
Human meningoma, QM103 |
| GSM6542870 |
Human meningoma, QM105 |
| GSM6542871 |
Human meningoma, QM106 |
| GSM6542872 |
Human meningoma, QM108 |
| GSM6542873 |
Human meningoma, QM109 |
| GSM6542874 |
Human meningoma, QM110 |
| GSM6542875 |
Human meningoma, QM113 |
| GSM6542876 |
Human meningoma, QM119 |
| GSM6542877 |
Human meningoma, QM124 |
| GSM6542878 |
Human meningoma, QM127 |
| GSM6542879 |
Human meningoma, QM131 |
| GSM6542880 |
Human meningoma, QM139 |
| GSM6542881 |
Human meningoma, QM140 |
| GSM6542882 |
Human meningoma, QM142 |
| GSM6542883 |
Human meningoma, QM154 |
| GSM6542884 |
Human meningoma, QM155 |
| GSM6542885 |
Human meningoma, QM158 |
| GSM6542886 |
Human meningoma, QM161 |
| GSM6542887 |
Human meningoma, QM162 |
| GSM6542888 |
Human meningoma, QM163 |
| GSM6542889 |
Human meningoma, QM164 |
| GSM6542890 |
Human meningoma, QM168 |
| GSM6542891 |
Human meningoma, QM172 |
| GSM6542892 |
Human meningoma, QM177 |
| GSM6542893 |
Human meningoma, QM179 |
| GSM6542894 |
Human meningoma, QM181 |
| GSM6542895 |
Human meningoma, QM183 |
| GSM6542896 |
Human meningoma, QM187 |
| GSM6542897 |
Human meningoma, QM188 |
| GSM6542898 |
Human meningoma, QM192 |
| GSM6542899 |
Human meningoma, QM198 |
| GSM6542900 |
Human meningoma, QM199 |
| GSM6542901 |
Human meningoma, QM200 |
| GSM6542902 |
Human meningoma, QM203 |
| GSM6542903 |
Human meningoma, QM205 |
| GSM6542904 |
Human meningoma, QM206 |
| GSM6542905 |
Human meningoma, QM207 |
| GSM6542906 |
Human meningoma, QM211 |
| GSM6542907 |
Human meningoma, QM212 |
| GSM6542908 |
Human meningoma, QM213 |
| GSM6542909 |
Human meningoma, QM214 |
| GSM6542910 |
Human meningoma, QM218 |
| GSM6542911 |
Human meningoma, QM220 |
| GSM6542912 |
Human meningoma, QM225 |
| GSM6542913 |
Human meningoma, QM226 |
| GSM6542914 |
Human meningoma, QM227 |
| GSM6542915 |
Human meningoma, QM228 |
| GSM6542916 |
Human meningoma, QM231 |
| GSM6542917 |
Human meningoma, QM235 |
| GSM6542918 |
Human meningoma, QM236 |
| GSM6542919 |
Human meningoma, QM239 |
| GSM6542920 |
Human meningoma, QM245 |
| GSM6542921 |
Human meningoma, QM248 |
| GSM6542922 |
Human meningoma, QM249 |
| GSM6542923 |
Human meningoma, QM256 |
| GSM6542924 |
Human meningoma, QM258 |
| GSM6542925 |
Human meningoma, QM260 |
| GSM6542926 |
Human meningoma, QM267 |
| GSM6542927 |
Human meningoma, QM269 |
| GSM6542928 |
Human meningoma, QM271 |
| GSM6542929 |
Human meningoma, QM272 |
| GSM6542930 |
Human meningoma, QM273 |
| GSM6542931 |
Human meningoma, QM274 |
| GSM6542932 |
Human meningoma, QM280 |
| GSM6542933 |
Human meningoma, QM282 |
| GSM6542934 |
Human meningoma, QM285 |
| GSM6542935 |
Human meningoma, QM286 |
| GSM6542936 |
Human meningoma, QM290 |
| GSM6542937 |
Human meningoma, QM291 |
| GSM6542938 |
Human meningoma, QM292 |
| GSM6542939 |
Human meningoma, QM297 |
| GSM6542940 |
Human meningoma, QM300 |
| GSM6542941 |
Human meningoma, QM302 |
| GSM6542942 |
Human meningoma, QM304 |
| GSM6542943 |
Human meningoma, QM313 |
| GSM6542944 |
Human meningoma, QM315 |
| GSM6542945 |
Human meningoma, QM316 |
| GSM6542946 |
Human meningoma, QM317 |
| GSM6542947 |
Human meningoma, QM318 |
| GSM6542948 |
Human meningoma, QM321 |
| GSM6542949 |
Human meningoma, QM322 |
| GSM6542950 |
Human meningoma, QM324 |
| GSM6542951 |
Human meningoma, QM325 |
| GSM6542952 |
Human meningoma, QM326 |
| GSM6542953 |
Human meningoma, QM329 |
| GSM6542954 |
Human meningoma, QM330 |
| GSM6542955 |
Human meningoma, QM332 |
| GSM6542956 |
Human meningoma, QM333 |
| GSM6542957 |
Human meningoma, QM339 |
| GSM6542958 |
Human meningoma, QM340 |
| GSM6542959 |
Human meningoma, QM341 |
| GSM6542960 |
Human meningoma, QM357 |
| GSM6542961 |
Human meningoma, QM348 |
| GSM6542962 |
Human meningoma, QM350 |
| GSM6542963 |
Human meningoma, QM351 |
| GSM6542964 |
Human meningoma, QM352 |
| GSM6542965 |
Human meningoma, QM354 |
| GSM6542966 |
Human meningoma, QM355 |
| GSM6542967 |
Human meningoma, QM343 |
| GSM6542968 |
Human meningoma, QM358 |
| GSM6542969 |
Human meningoma, QM359 |
| GSM6542970 |
Human meningoma, QM360 |
| GSM6542971 |
Human meningoma, QM362 |
| GSM6542972 |
Human meningoma, QM364 |
| GSM6542973 |
Human meningoma, QM367 |
| GSM6542974 |
Human meningoma, QM369 |
| GSM6542975 |
Human meningoma, QM374 |
| GSM6542976 |
Human meningoma, QM375 |
| GSM6542977 |
Human meningoma, QM379 |
| GSM6542978 |
Human meningoma, QM10 |
| GSM6542979 |
Human meningoma, QM35 |
| GSM6542980 |
Human meningoma, QM43 |
| GSM6542981 |
Human meningoma, QM61 |
| GSM6542982 |
Human meningoma, QM63 |
| GSM6542983 |
Human meningoma, QM68 |
| GSM6542984 |
Human meningoma, QM72 |
| GSM6542985 |
Human meningoma, QM73 |
| GSM6542986 |
Human meningoma, QM74 |
| GSM6542987 |
Human meningoma, QM81 |
| GSM6542988 |
Human meningoma, QM84 |
| GSM6542989 |
Human meningoma, QM85 |
| GSM6542990 |
Human meningoma, QM89 |
| GSM6542991 |
Human meningoma, QM99 |
| GSM6542992 |
Human meningoma, QM101 |
| GSM6542993 |
Human meningoma, QM104 |
| GSM6542994 |
Human meningoma, QM107 |
| GSM6542995 |
Human meningoma, QM111 |
| GSM6542996 |
Human meningoma, QM112 |
| GSM6542997 |
Human meningoma, QM116 |
| GSM6542998 |
Human meningoma, QM117 |
| GSM6542999 |
Human meningoma, QM118 |
| GSM6543000 |
Human meningoma, QM121 |
| GSM6543001 |
Human meningoma, QM129 |
| GSM6543002 |
Human meningoma, QM130 |
| GSM6543003 |
Human meningoma, QM133 |
| GSM6543004 |
Human meningoma, QM136 |
| GSM6543005 |
Human meningoma, QM137 |
| GSM6543006 |
Human meningoma, QM138 |
| GSM6543007 |
Human meningoma, QM141 |
| GSM6543008 |
Human meningoma, QM146 |
| GSM6543009 |
Human meningoma, QM148 |
| GSM6543010 |
Human meningoma, QM152 |
| GSM6543011 |
Human meningoma, QM156 |
| GSM6543012 |
Human meningoma, QM157 |
| GSM6543013 |
Human meningoma, QM159 |
| GSM6543014 |
Human meningoma, QM160 |
| GSM6543015 |
Human meningoma, QM169 |
| GSM6543016 |
Human meningoma, QM170 |
| GSM6543017 |
Human meningoma, QM171 |
| GSM6543018 |
Human meningoma, QM174 |
| GSM6543019 |
Human meningoma, QM175 |
| GSM6543020 |
Human meningoma, QM182 |
| GSM6543021 |
Human meningoma, QM189 |
| GSM6543022 |
Human meningoma, QM193 |
| GSM6543023 |
Human meningoma, QM195 |
| GSM6543024 |
Human meningoma, QM197 |
| GSM6543025 |
Human meningoma, QM202 |
| GSM6543026 |
Human meningoma, QM209 |
| GSM6543027 |
Human meningoma, QM215 |
| GSM6543028 |
Human meningoma, QM219 |
| GSM6543029 |
Human meningoma, QM221 |
| GSM6543030 |
Human meningoma, QM222 |
| GSM6543031 |
Human meningoma, QM229 |
| GSM6543032 |
Human meningoma, QM230 |
| GSM6543033 |
Human meningoma, QM232 |
| GSM6543034 |
Human meningoma, QM233 |
| GSM6543035 |
Human meningoma, QM238 |
| GSM6543036 |
Human meningoma, QM240 |
| GSM6543037 |
Human meningoma, QM242 |
| GSM6543038 |
Human meningoma, QM247 |
| GSM6543039 |
Human meningoma, QM250 |
| GSM6543040 |
Human meningoma, QM251 |
| GSM6543041 |
Human meningoma, QM253 |
| GSM6543042 |
Human meningoma, QM254 |
| GSM6543043 |
Human meningoma, QM255 |
| GSM6543044 |
Human meningoma, QM259 |
| GSM6543045 |
Human meningoma, QM261 |
| GSM6543046 |
Human meningoma, QM262 |
| GSM6543047 |
Human meningoma, QM263 |
| GSM6543048 |
Human meningoma, QM264 |
| GSM6543049 |
Human meningoma, QM266 |
| GSM6543050 |
Human meningoma, QM268 |
| GSM6543051 |
Human meningoma, QM270 |
| GSM6543052 |
Human meningoma, QM276 |
| GSM6543053 |
Human meningoma, QM277 |
| GSM6543054 |
Human meningoma, QM283 |
| GSM6543055 |
Human meningoma, QM287 |
| GSM6543056 |
Human meningoma, QM289 |
| GSM6543057 |
Human meningoma, QM298 |
| GSM6543058 |
Human meningoma, QM299 |
| GSM6543059 |
Human meningoma, QM308 |
| GSM6543060 |
Human meningoma, QM311 |
| GSM6543061 |
Human meningoma, QM314 |
| GSM6543062 |
Human meningoma, QM320 |
| GSM6543063 |
Human meningoma, QM323 |
| GSM6543064 |
Human meningoma, QM327 |
| GSM6543065 |
Human meningoma, QM331 |
| GSM6543066 |
Human meningoma, QM335 |
| GSM6543067 |
Human meningoma, QM336 |
| GSM6543068 |
Human meningoma, QM337 |
| GSM6543069 |
Human meningoma, QM344 |
| GSM6543070 |
Human meningoma, QM345 |
| GSM6543071 |
Human meningoma, QM346 |
| GSM6543072 |
Human meningoma, QM353 |
| GSM6543073 |
Human meningoma, QM361 |
| GSM6543074 |
Human meningoma, QM365 |
| GSM6543075 |
Human meningoma, QM366 |
| GSM6543076 |
Human meningoma, QM368 |
| GSM6543077 |
Human meningoma, QM370 |
| GSM6543078 |
Human meningoma, QM371 |
| GSM6543079 |
Human meningoma, QM373 |
| GSM6543080 |
Human meningoma, QM377 |
| GSM6543081 |
Human meningoma, QM378 |
| GSM6543082 |
Human meningoma, QM381 |
| GSM6543083 |
Human meningoma, QM384 |
| GSM6543084 |
Human meningoma, QM385 |
| GSM6543085 |
Human meningoma, QM387 |
| GSM6543086 |
Human meningoma, QM388 |
| GSM6543087 |
Human meningoma, QM389 |
| GSM6543088 |
Human meningoma, QM390 |
| GSM6543089 |
Human meningoma, QM395 |
| GSM6543090 |
Human meningoma, QM396 |
| GSM6543091 |
Human meningoma, QM397 |
| GSM6543092 |
Human meningoma, QM400 |
| GSM6543093 |
Human meningoma, QM401 |
| GSM6543094 |
Human meningoma, QM402 |
| GSM6543095 |
Human meningoma, QM403 |
| GSM6543096 |
Human meningoma, QM405 |
| GSM6543097 |
Human meningoma, QM406 |
| GSM6543098 |
Human meningoma, QM410 |
| GSM6543099 |
Human meningoma, QM411 |
| GSM6543100 |
Human meningoma, QM414 |
| GSM6543101 |
Human meningoma, QM420 |
| GSM6543102 |
Human meningoma, QM153 |
| GSM6543103 |
Human meningoma, QM173 |
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| Relations |
| BioProject |
PRJNA876719 |
| SRA |
SRP395524 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE212666_RAW.tar |
1.4 Gb |
(http)(custom) |
TAR (of TAR) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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