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Series GSE212849 Query DataSets for GSE212849
Status Public on Sep 08, 2022
Title Prediction of Golimumab Response in the PROgECT Phase 2a Open-Label Trial of Patients With Ulcerative Colitis
Organism Homo sapiens
Experiment type Expression profiling by array
Summary PROgECT (ClinicalTrials.gov Identifier: NCT01988961) was a multicenter, open-label study evaluating the accuracy of a probe-set panel in predicting response to golimumab treatment in participants with moderately to severely active ulcerative colitis (UC). Biopsy samples (collected 15 to 20 cm from the anal verge) were taken at screening from 84 patients and used for RNA extraction and profiling by microarrays. All patients enrolled in the study received the approved induction dose regimen of subcutaneous (SC) golimumab.
 
Overall design A gene expression profiling study was conducted in which colon biopsy samples were collected for RNA extraction and hybridization to microarrays from patients (n=84) with moderate-to-severe ulcerative colitis.
 
Contributor(s) Pavlidis P, Tsakmaki A, Pantazi E, Li K, Cozzetto D, Digby-Bell J, Yang F, Lo J, Alberts E, Costa Sa AC, Niazi U, Friedman J, Long A, Ding Y, Carey C, Lamb C, Saqi M, Madgwick M, Gul L, Treveil A, Korcsmaros T, MacDonald T, Lord G, Bewick G, Powell N
Citation(s) 36170836
Submission date Sep 07, 2022
Last update date Dec 08, 2022
Contact name Nick Powell
E-mail(s) npowell@ic.ac.uk
Organization name Imperial College London
Department Department of Metabolism, Digestion and Reproduction
Street address Du Cane Road
City London
ZIP/Postal code W12 0NN
Country United Kingdom
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (84)
GSM6557038 CNTO148UCO2001-100002 colon biopsy week 0
GSM6557039 CNTO148UCO2001-100003 colon biopsy week 0
GSM6557041 CNTO148UCO2001-100007 colon biopsy week 0
Relations
BioProject PRJNA877642

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE212849_RAW.tar 412.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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