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| Status |
Public on Sep 12, 2023 |
| Title |
High concentration of adrenaline blocks key cell cycle genes and exhibits antifibrotic and vasoconstrictor effects in glaucoma surgery |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the effects of adrenaline on fibrosis in glaucoma surgery. Human Tenon’s fibroblasts (HTFs) were treated with adrenaline (0%, 0.0005%, 0.01%) for 24 hours and RNA-Sequencing was performed on the Illumina NextSeq2000. We carried out detailed gene ontology, pathway, disease and drug enrichment analyses.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for HTFs treated with different concentrations of adrenaline (0%, 0.0005%, 0.01%).
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| Contributor(s) |
Yu-Wai-Man C |
| Citation(s) |
37429521 |
| Submission date |
Sep 12, 2022 |
| Last update date |
Dec 13, 2023 |
| Contact name |
Cynthia Yu-Wai-Man |
| E-mail(s) |
cynthia.yu-wai-man@kcl.ac.uk
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| Organization name |
King's College London
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| Street address |
Westminster Bridge Road
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| City |
London |
| ZIP/Postal code |
SE1 7EH |
| Country |
United Kingdom |
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| Platforms (1) |
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| Samples (9)
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| GSM6574554 |
Human Tenon's fibroblasts, Control 1, Day1 |
| GSM6574555 |
Human Tenon's fibroblasts, Control 2, Day1 |
| GSM6574556 |
Human Tenon's fibroblasts, Control 3, Day1 |
| GSM6574557 |
Human Tenon's fibroblasts, 0.0005% Adrenaline 1, Day1 |
| GSM6574558 |
Human Tenon's fibroblasts, 0.0005% Adrenaline 2, Day1 |
| GSM6574559 |
Human Tenon's fibroblasts, 0.0005% Adrenaline 3, Day1 |
| GSM6574560 |
Human Tenon's fibroblasts, 0.01% Adrenaline 1, Day1 |
| GSM6574561 |
Human Tenon's fibroblasts, 0.01% Adrenaline 2, Day1 |
| GSM6574562 |
Human Tenon's fibroblasts, 0.01% Adrenaline 3, Day1 |
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| Relations |
| BioProject |
PRJNA879766 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE213217_Adrenaline0.0005_vsControl.complete.txt.gz |
1.3 Mb |
(ftp)(http) |
TXT |
| GSE213217_Adrenaline0.01_vsAdrenaline0.0005_.complete.txt.gz |
1.3 Mb |
(ftp)(http) |
TXT |
| GSE213217_Adrenaline0.01_vsControl.complete.txt.gz |
1.3 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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