|
| Status |
Public on Sep 01, 2024 |
| Title |
Doxorubicin and protective inhibitor treated iPSC derived cardiomyocytes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Investigation of drug and gene rescues doxorubicin induced alterations of transcriptomic and metabolic profiles
|
| |
|
| Overall design |
RNA-seq analysis on 1) WT and CA12 KO iCMs treated with vehicle or doxorubicin (0.5 µM) and 2) WT iCMs treated with doxorubicin plus indisulam to gain a comprehensive understanding of their genome-wide transcriptomic changes.
|
| |
|
| Contributor(s) |
Liu C, Shen M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Sep 14, 2022 |
| Last update date |
Sep 01, 2024 |
| Contact name |
Chun Liu |
| E-mail(s) |
liuchun@stanford.edu
|
| Organization name |
stanford
|
| Street address |
1291 Welch Road BMI building, 3200-CVI Rm
|
| City |
palo alto |
| State/province |
CA |
| ZIP/Postal code |
94304 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
|
| Samples (10)
|
| GSM6578662 |
Wildtype (WT) iCMs treated with DMSO 1 |
| GSM6578663 |
Wildtype (WT) iCMs treated with DMSO 2 |
| GSM6578664 |
Wildtype (WT) iCMs treated with doxorubicin 1 |
| GSM6578665 |
Wildtype (WT) iCMs treated with doxorubicin 2 |
| GSM6578666 |
Wildtype (WT) iCMs treated with doxorubicin and indisulam 1 |
| GSM6578667 |
Wildtype (WT) iCMs treated with doxorubicin and indisulam 2 |
| GSM6578668 |
CA12 knockout (KO) iCMs treated with DMSO 1 |
| GSM6578669 |
CA12 knockout (KO) iCMs treated with DMSO 2 |
| GSM6578670 |
CA12 knockout (KO) iCMs treated with doxorubicin 1 |
| GSM6578671 |
CA12 knockout (KO) iCMs treated with doxorubicin 2 |
|
| Relations |
| BioProject |
PRJNA880508 |
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