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| Status |
Public on Sep 16, 2022 |
| Title |
Clinical and pathological findings in neurolymphomatosis: preliminary association with gene expression profiles in sural nerves. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Although inflammation appears to play a role in neurolymphomatosis (NL), the mechanisms leading to degeneration in the peripheral nervous system are poorly understood. The purpose of this exploratory study was to identify molecular pathways underlying NL pathogenesis, combining clinical and neuropathological investigation with gene expression (GE) studies. Based on the neuropathic symptoms and signs, NL patients were classified into three forms of neuropathy: chronic symmetrical sensorimotor polyneuropathy (SMPN, n=3), multiple mononeuropathy (MN, n=4) and acute motor-sensory axonal neuropathy (AMSAN, n=1). Predominantly diffuse malignant cells infiltration of epineurium was present in chronic SMPN, whereas endoneurial perivascular cells invasion was observed in MN. In contrast, diffuse endoneurium malignant cells localization occurred in AMSAN. We identified alterations in the expression of 1266 genes, with 115 up-regulated and 1151 down-regulated genes, which were mainly associated with ribosomal proteins (RP) and olfactory receptors (OR) signaling pathways, respectively. Among the top up-regulated genes were actin alpha 1 skeletal muscle (ACTA1) and desmin (DES). Similarly, in NL nerves ACTA1, DES and several RPs were highly expressed, associated with endothelial cells and pericytes abnormalities. Peripheral nerve involvement may be due to conversion towards a more aggressive phenotype, potentially explaining the poor prognosis. The candidate genes reported in this study may be a source of clinical biomarkers for NL.
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| Overall design |
The purpose of this exploratory study was to identify molecular pathways underlying NL pathogenesis, combining clinical and neuropathological investigation with gene expression (GE) studies. We characterized the clinical and pathological features of eight patients with NL. We further analysed GE changes in sural nerve biopsies obtained from a subgroup of NL patients (n=3) and thirteen patients with inflammatory neuropathies as neuropathic controls.
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| Contributor(s) |
Clarelli F, Domi T, Cerri F, Santoro S, Nilo R, Quattrini A |
| Citation(s) |
36226068 |
| Submission date |
Sep 15, 2022 |
| Last update date |
Oct 28, 2022 |
| Contact name |
Nilo Riva |
| E-mail(s) |
nilomnd@gmail.com
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| Phone |
+ 39 340 7891034
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| Organization name |
IRCCS San Raffaele
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| Department |
Neuroscience
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| Lab |
Experimental Neuropathology Unit
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| Street address |
via Olgettina 60
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| City |
Milan |
| ZIP/Postal code |
22070 |
| Country |
Italy |
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| Platforms (1) |
| GPL13369 |
Illumina Human Whole-Genome DASL HT |
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| Samples (16)
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| GSM6586606 |
sural nerve_biopsy_diagnostic_vasculitic neuropathy 1 |
| GSM6586607 |
sural nerve_biopsy_diagnostic_vasculitic neuropathy 2 |
| GSM6586608 |
sural nerve_biopsy_diagnostic_vasculitic neuropathy 3 |
| GSM6586609 |
sural nerve_biopsy_diagnostic_vasculitic neuropathy 4 |
| GSM6586610 |
sural nerve_biopsy_diagnostic_vasculitic neuropathy 5 |
| GSM6586611 |
sural nerve_biopsy_diagnostic_vasculitic neuropathy 6 |
| GSM6586612 |
sural nerve_biopsy_diagnostic_vasculitic neuropathy 7 |
| GSM6586613 |
sural nerve_biopsy_diagnostic_vasculitic neuropathy 8 |
| GSM6586614 |
sural nerve_biopsy_diagnostic_vasculitic neuropathy 9 |
| GSM6586615 |
sural nerve_biopsy_diagnostic_inflammatory neuropathy 1 |
| GSM6586616 |
sural nerve_biopsy_diagnostic_inflammatory neuropathy 2 |
| GSM6586617 |
sural nerve_biopsy_diagnostic_inflammatory neuropathy 3 |
| GSM6586618 |
sural nerve_biopsy_diagnostic_inflammatory neuropathy 4 |
| GSM6586619 |
sural nerve_biopsy_diagnostic_Lymphomatous neuropathy 1 |
| GSM6586620 |
sural nerve_biopsy_diagnostic_Lymphomatous neuropathy 2 |
| GSM6586621 |
sural nerve_biopsy_diagnostic_Lymphomatous neuropathy 3 |
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| Relations |
| BioProject |
PRJNA880872 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE213455_non-normalized.txt.gz |
5.0 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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