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Series GSE213928 Query DataSets for GSE213928
Status Public on Jun 30, 2023
Title Profiling of glycerol-induced models of muscle regeneration upon melatonin treatment for 14 days in mice
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Intramuscular injection of glycerol (Gly) has been reported to lead to skeletal muscle regeneration and ectopic fat deposition. We utilized glycerol injections in the tibialis anterior muscles to investigate the effects of melatonin on skeletal muscle regeneration and intramuscular fat infiltration. We characterized genome-wide expression profiles of tibialis anterior muscles from wild-type mice injured by glycerol injection following melatonin intervention. Mice that were treated with melatonin exhibited improved muscle regeneration and reduced intramuscular fat deposition, which were associated with enhanced myogenesis, remodeled lipid metabolism and reduced immune cell infiltration.
Overall design Transcriptomic profiling was performed on RNA derived from tibialis anterior muscle 14 days post glycerol injury following melatonin intervention. Tibialis anterior muscle of 12 week old wildtype C57BL/6J male mice were injected with glycerol were collected 14 days after injection. 3 biological replicates were used for each condition.
Contributor(s) Chen W, Ling D, Wang L, Zhou Y, Huang Y, Zhang S, You W, Wang Y, Shan T
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Submission date Sep 22, 2022
Last update date Jun 30, 2023
Contact name Chen Wentao
Phone 19817860607
Organization name Zhejiang University
Street address No. 866 Yuhangtang Road
City Hangzhou
State/province Zhejiang
ZIP/Postal code 310058
Country China
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (6)
GSM6596557 Glycerol rep1
GSM6596558 Glycerol rep2
GSM6596559 GlyceroI rep3
BioProject PRJNA883200

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Supplementary file Size Download File type/resource
GSE213928_Rawdata.txt.gz 239.3 Kb (ftp)(http) TXT
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