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| Status |
Public on Jan 01, 2011 |
| Title |
Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of gene expression profiles in skeletal muscle tissue after long-term use of HRT. Networks of enriched processes in skeletal muscle responding to long-term use of estrogen-based HRT in comparison with women without any HRT in a genetically controlled setting were contructed.
The association between the expression of specific biological processes and muscle composition or performance was tested. The hypothesis was that the differences in gene expression profiles reflect the known differences in muscle composition and performance.
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| Overall design |
Total RNA obtained from muscle biopsies (vastus lateralis) from genetically identical female twin pairs (n=11 pairs) of which one sister is a user of postmenopausal, estrogen-based HRT (n=11), while the other is a never-user (n=11).
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| |
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| Contributor(s) |
Ronkainen PH, Kovanen V |
| Citation(s) |
20883525 |
| |
| Submission date |
Apr 21, 2010 |
| Last update date |
Feb 18, 2019 |
| Contact name |
Paula Ronkainen |
| E-mail(s) |
paula.h.a.ronkainen@jyu.fi
|
| Organization name |
University of Jyväskylä
|
| Street address |
PO Box 35
|
| City |
Jyväskylä |
| ZIP/Postal code |
40014 |
| Country |
Finland |
| |
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| Platforms (1) |
| GPL6884 |
Illumina HumanWG-6 v3.0 expression beadchip |
|
| Samples (22)
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| Relations |
| BioProject |
PRJNA126371 |
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