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| Status |
Public on Nov 01, 2022 |
| Title |
RNA‐seq of comprehensively examine variations in MHCC-97H cells treated with various doses of lenvatinib at the transcriptomic level. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To determine the drug target of lenvatinib, RNAseq was used to evaluate the transcriptome differences between lenvatinib-treated MHCC-97H cells and their parental counterparts.Results show that SERPINE1 may be direct target of lenvatinib, and AKR1C1 have potential prognostic significance in the prediction of LR(lenvatinib-resistant) in HCC. AKR1C1 could be a promising therapeutic target for patients with LR-type liver cancer.
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| Overall design |
MHCC-97H cells treated with 40, 60, 80, and 100 μM lenvatinib, and RNAseq was used to evaluate the transcriptome differences between lenvatinib-treated MHCC-97H cells and their parental counterparts.For more information, please consult 1065152807@qq.com
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| Contributor(s) |
Chen Z, Gao C, Xu T, Lu C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Sep 27, 2022 |
| Last update date |
Nov 01, 2022 |
| Contact name |
Cheng Gao |
| E-mail(s) |
gc108802020@126.com
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| Organization name |
Affiliated Hospital of Nantong University
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| Street address |
20 Xisi Road
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| City |
Nantong |
| ZIP/Postal code |
226001 |
| Country |
China |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (8)
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| GSM6604237 |
MHCC-97H cells ,NC4, 24Hours |
| GSM6604238 |
MHCC-97H cells ,L1, 24Hours |
| GSM6604239 |
MHCC-97H cells ,L2, 24Hours |
| GSM6604240 |
MHCC-97H cells ,L3, 24Hours |
| GSM6604241 |
MHCC-97H cells ,L4, 24Hours |
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| Relations |
| BioProject |
PRJNA884761 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE214324_gene_expression.txt.gz |
1.6 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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