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| Status |
Public on Apr 27, 2010 |
| Title |
HORMAD1 mutation disrupts synaptonemal complex formation and chromosomal segregation in fertilized eggs |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Hormad1 encodes a protein that contains a HORMA domain, and unlike Mad2, Hormad1 expression is germ cell specific. We discovered that both male and female are infertile, and HORMAD1 has important function in synaptonemal complex formation, sex chromosome inactivation during spermatogenesis and chromosome segregation in meiosis.
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| |
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| Overall design |
RNA isolated from wild-type and Hormad1-/- 2-week-old testes was used for performing Illumina BeadChip MouseWG-6 2.0 arrays. Three replicates per genotype were performed.
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| |
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| Contributor(s) |
Shin Y, Ahn H |
| Citation(s) |
21079677 |
| |
| Submission date |
Apr 26, 2010 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Aleksandar Rajkovic |
| E-mail(s) |
rajkovic@upmc.edu
|
| Phone |
412-641-7457
|
| Fax |
412-641-8519
|
| Organization name |
Magee-Womens Research Institute
|
| Department |
Dept. of Obstetrics, Gynecology & Reproductive Sciences
|
| Street address |
204 Craft Ave. Suite A230
|
| City |
Pittsburgh |
| State/province |
PA |
| ZIP/Postal code |
15213 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (6)
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| Relations |
| BioProject |
PRJNA125949 |
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