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| Status |
Public on Feb 21, 2023 |
| Title |
Cerebral malaria is regulated by host mediated changes in Plasmodium gene expression |
| Organisms |
Plasmodium berghei; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Cerebral Malaria (CM), the deadliest complication of Plasmodium infection, is a complex and unpredictable disease. Currently, our understanding of the factors that trigger progression of malaria to CM is limited. Here, by infecting experimental CM (ECM) resistant (Balb/c) and ECM susceptible (C57BL/6) mice with ECM causing (ANKA) and non-ECM causing (NK65) Plasmodium berghei (Pb) parasite strains, we revealed that in resistant host, infection by ECM causing parasite develops similar to infection by non-ECM causing parasite in susceptible host in terms of parasite growth in host, disease course and host immune response against parasite. Our comparative gene expression analysis revealed that in Balb/c host, gene expression of Pb ANKA parasite is remarkably different from, the gene expression of Pb ANKA in C57BL/6 but similar to the gene expression of non-ECM causing Pb NK65 in C57BL/6. Thus, host has a critical influence on parasite behavior which ultimately determines the course of malaria disease.
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| Overall design |
different treatments of Plasmodium compared
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| Contributor(s) |
Cimperman CK, Pena M, Gokcek SM, Theall BP, Patel MV, Sharma A, Qi C, Sturdevant D, Collins PL, Pierce SK, Akkaya M |
| Citation(s) |
36852995 |
| Submission date |
Oct 12, 2022 |
| Last update date |
May 12, 2023 |
| Contact name |
Dan Sturdevant |
| E-mail(s) |
dsturdevant@niaid.nih.gov
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| Phone |
4063639248
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| Organization name |
NIH
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| Department |
NIAID
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| Lab |
RTS
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| Street address |
903 S 4th street
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| City |
Hamilton |
| State/province |
MT |
| ZIP/Postal code |
59840 |
| Country |
USA |
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| Platforms (1) |
| GPL32741 |
Illumina NextSeq 500 (Mus musculus; Plasmodium berghei) |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA889842 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE215359_matrix_path.txt.gz |
166.7 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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