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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 06, 2023 |
| Title |
Osteosarcoma cells-derived secretome induce pre-metastatic changes in the lung microenvironment that support lung metastasis formation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
To investigate the molecular and cellular alterations occurring in the lung tissue during the pre-metastatic niche formation in osteosarcoma, we used two different approaches in which mice were implanted subcutaneously with the 143B OS cells for a primary tumour (PT) formation or treated with the 143B cell-derived secretome (SCR) to mimic the release of secreted factors by a locally primary tumour.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data of the lung tissue collected from control, SCR-treated or PT-bearing mice.
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| Contributor(s) |
Almeida SF, Ribeiro G, Santos L, Lima N, Abreu M, Caetano R, Zuzarte M, Paiva A, Martins-Marques T, Girao H, Ribeiro AS, Miranda C, Pereira de Almeida L, Falcao A, Abrunhosa A, Gomes C |
| Citation(s) |
38031171 |
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| Submission date |
Oct 27, 2022 |
| Last update date |
Dec 06, 2023 |
| Contact name |
Rekin's Janky |
| E-mail(s) |
Nucleomics.Bioinformatics@vib.be
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| Organization name |
VIB
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| Department |
Nucleomics Core
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| Street address |
Herestraat 49 Box 816
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| City |
Leuven |
| ZIP/Postal code |
B-3000 |
| Country |
Belgium |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA895082 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE216744_exp3782-RNAseqCounts.xlsx |
8.9 Mb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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