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| Status |
Public on Nov 22, 2022 |
| Title |
The brain regulatory program predates central nervous system evolution |
| Organism |
Nematostella vectensis |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Understanding how brains evolved is critical to determine the origin(s) of centralized nervous systems. Brains are patterned along their anteroposterior axis by stripes of gene expression that appear to be conserved, suggesting brains are homologous. However, the striped expression is also part of the deeply conserved anteroposterior axial program. An emerging hypothesis is that similarities in brain patterning are convergent, arising through the repeated co-option of axial programs. To resolve whether shared brain neurogenic programs likely reflect convergence or homology, we investigated the evolution of axial programs in neurogenesis. We show that the bilaterian anteroposterior program patterns the nerve net of the cnidarian Nematostella along the oral-aboral axis arguing that anteroposterior programs regionalized developing nervous systems in the cnidarian-bilaterian common ancestor prior to the emergence of brains. This finding rejects shared patterning as sufficient evidence to support brain homology and provides functional support for the plausibility that axial programs could be co-opted if nervous systems centralized in multiple lineages
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| Overall design |
Single cell analysis of 24 hour post fertilization Nematostella vectensis gastrula with 4 technical replicates sequenced from the same original pool of isolated gastrula
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| Contributor(s) |
Faltine-Gonzalez DZ, Havrilak JA, Layden MJ |
| Citation missing |
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| Submission date |
Nov 21, 2022 |
| Last update date |
Nov 24, 2022 |
| Contact name |
Michael John Layden |
| E-mail(s) |
laydenbio@gmail.com
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| Phone |
8083522384
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| Organization name |
Lehigh University
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| Department |
Biological Sciences
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| Lab |
Layden Lab
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| Street address |
111 Research Dr
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| City |
Bethlehem |
| State/province |
PA |
| ZIP/Postal code |
18015 |
| Country |
USA |
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| Platforms (1) |
| GPL29226 |
Illumina NovaSeq 6000 (Nematostella vectensis) |
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| Samples (4)
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| GSM6744435 |
24hr Gastrula Cells, replicate 1, scRNAseq |
| GSM6744436 |
24hr Gastrula Cells, replicate 2, scRNAseq |
| GSM6744437 |
24hr Gastrula Cells, replicate 3, scRNAseq |
| GSM6744438 |
24hr Gastrula Cells, replicate 4, scRNAseq |
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| Relations |
| BioProject |
PRJNA903823 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE218419_RAW.tar |
128.9 Mb |
(http)(custom) |
TAR (of MTX, TSV) |
| GSE218419_stella.filter1.Rdata.gz |
2.4 Gb |
(ftp)(http) |
RDATA |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
| Processed data are available on Series record |
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