NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE22070 Query DataSets for GSE22070
Status Public on Jun 03, 2010
Title Whole tissue mRNA expression from severely obese individuals: subcutaneous and visceral adipose tissues
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Subcutaneous adipose tissue and visceral adipose tissue samples were obtained from severely obese individuals that underwent bariatric surgery.
The goal of this study was to compare genome-wide gene expression levels in the two tissue types from healthy and unhealthy severely obese individuals.
Whole-transcriptome subcutaneous adipose tissue gene expression levels were determined in 73 individuals with a BMI >35 kg/m2.
Whole-transcriptome visceral adipose tissue gene expression levels were determined in 69 individuals with a BMI >35 kg/m2.
Modules of co-expressed genes likely to be functionally related were identfied and correlated with BMI, plasma levels of glucose, insulin, HbA1c, triglycerides, non-esterified fatty acids, ALAT, ASAT, C-reactive protein, and LDL- and HDL cholesterol.
 
Overall design Gene expression data was determined for untreated whole subcutaneous adipose tissue (n=73) from unrelated Dutch severely obese individuals.
Gene expression data was determined for untreated whole visceral adipose tissue (n=69) from unrelated Dutch severely obese individuals.
 
Contributor(s) Wolfs M, Rensen S, Bruin-van Dijk E, Verdam F, Greve J, Sanjabi B, Bruinenberg M, Wijmenga C, van Haeften T, Buurman W, Franke L, Hofker M
Citation(s) 20687939, 21829388, 25282492, 22275870
Submission date Jun 01, 2010
Last update date Oct 31, 2019
Contact name Lude Franke
E-mail(s) lude@ludesign.nl
Phone +316 41549962
Organization name University Medical Centre Groningen
Department Genetics
Lab Genetics
Street address P.O. Box 30001
City Groningen
State/province Groningen
ZIP/Postal code 9700 RR
Country Netherlands
 
Platforms (1)
GPL6947 Illumina HumanHT-12 V3.0 expression beadchip
Samples (142)
GSM548649 Whole subcutaneous adipose tissue RNA from Dutch severely obese individual 92
GSM548650 Whole subcutaneous adipose tissue RNA from Dutch severely obese individual 51
GSM548651 Whole subcutaneous adipose tissue RNA from Dutch severely obese individual 63
Relations
BioProject PRJNA128947

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE22070_RAW.tar 41.0 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap