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| Status |
Public on Jun 30, 2023 |
| Title |
Effects of CDK8/19 Mediator Kinase inhibition by Senexin B on gene expression in HEK293 cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA-Seq analysis was carried out to investigate the effects of selective CDK8/19 inhibitor Senexin B on gene expression in HEK293 cells (293-WT) or the CDK8/19 double-knockout (293-dKO) derivatives.
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| Overall design |
293-WT or 293-dKO cells were treated with 0.1% DMSO (vehicle control) or 1 μM Senexin B for 24 or 72 hours. Each treatment condition was done in biological triplicate.
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| |
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| Contributor(s) |
Chen M, Ji H, Roninson IB |
| Citation(s) |
37378433 |
| |
| Submission date |
Dec 16, 2022 |
| Last update date |
Aug 21, 2023 |
| Contact name |
HAO JI |
| E-mail(s) |
ji5@email.sc.edu
|
| Phone |
8037774689
|
| Organization name |
University of South Carolina
|
| Department |
College of Pharmacy
|
| Street address |
715 SUMTER ST CLS RM 109
|
| City |
COLUMBIA |
| State/province |
SC |
| ZIP/Postal code |
29208 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA913131 |
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