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| Status |
Public on Mar 01, 2023 |
| Title |
Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans [Rep-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Other
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| Summary |
BCR repertoire sequencing data from influenza vaccinated subjects.
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| Overall design |
Three healthy subjects had blood drawn at various time points following IM influenza vaccine. Cells were sort purified to obtain naive B cells, plasmablasts, flu (HA) specific memory B cells (FcRL5+ and FcRL5neg) and IgD negative memory B cells. Donor 1 had HA-specific memory B cells for 7 and 14 days post vaccine; Donor 2 had HA-specific memory B cells 7 days post vaccine; Donor 3 had HA-specific memory B cells 14 and 28 days post vaccine. All donors had IgD negative memory B cells 120 days post vaccine, naive B cells for either 7 or 14 days post vaccine and plasmablasts 7 days post vaccine in years 1 and 2. These samples were used for repertoire analysis by deep sequencing.
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| Contributor(s) |
Nellore A, Zumaquero E, Scharer CD, Fucile CF, Tipton CM, King RG, Mi T, Mousseau B, Bradley JE, Zhou F, Mutneja S, Goepfert PA, Boss JM, Randall TD, Sanz I, Rosenberg AF, Lund FE |
| Citation(s) |
36958335 |
| |
| Submission date |
Jan 09, 2023 |
| Last update date |
Jun 05, 2023 |
| Contact name |
Alexander Rosenberg |
| E-mail(s) |
afr@uab.edu
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| Organization name |
University of Alabama at Birmingham
|
| Street address |
1720 2nd Avenue South, Suite 276/11
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| City |
Birmingham |
| State/province |
AL |
| ZIP/Postal code |
35294 |
| Country |
USA |
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| Platforms (1) |
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| Samples (23)
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| This SubSeries is part of SuperSeries: |
| GSE222476 |
Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans |
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| Relations |
| BioProject |
PRJNA922176 |
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