 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Dec 27, 2023 |
| Title |
Gene expression signatures of megakaryocytes post-IR |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Platelets are anucleated blood cells that are produced by their progenitor cell, the megakaryocyte (MK). Platelets are centrally positioned in hemostasis and thrombosis and, according to the recent findings, play key roles in innate immunity, inflammation, atherogenesis, and cancer metastasis. The quantitative and qualitative properties of platelets are crucial determinants of their hemostatic function. While the regulatory mechanisms of platelet number and size have been studied separately, critical questions remain regarding the interplay of platelet number and size in hemostasis. In this study, using a mouse model of irradiation (IR)-induced thrombocytopenia, we show that mature MKs (mMKs) are resistant to IR and maintain the nadir platelet levels post IR. To identify the phenotype switching and function variation in BM MKs post IR, we performed microarray expression profiling of MKs from the bone marrow of mice at 1- or 3-days post IR and control mice (Ctrl).
|
| |
|
| Overall design |
Radiation induced gene expression in MK was measured at 1 and 3 days after exposure to doses of 5 Gy g-rays. Three independent experiments were performed at each time using different donors for each experiment.
|
| |
|
| Contributor(s) |
Wu Y, Liao W |
| Citation(s) |
38111039, 38802843 |
| |
| Submission date |
Jan 10, 2023 |
| Last update date |
Jun 05, 2024 |
| Contact name |
Weinian Liao |
| E-mail(s) |
wnliao@tmmu.edu.cn
|
| Phone |
15111956240
|
| Organization name |
Army Medical University
|
| Street address |
Gaotanyan street 30
|
| City |
Chongqing |
| ZIP/Postal code |
400038 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL33010 |
Agilent-074809 SurePrint G3 Mouse Gene Expression v2 8x60K Microarray [Gene-based version] |
|
| Samples (9)
|
|
| Relations |
| BioProject |
PRJNA922441 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE222512_RAW.tar |
112.7 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
|
|
|
|
 |
Less...
More...