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| Status |
Public on Jan 01, 2024 |
| Title |
A549 cigarette smoke resistant cell line expression profiling |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Chronic obstructive pulmonary disease (COPD) is currently the third cause of death worldwide with still increasing mortality and morbidity. Primary etiology of COPD is cigarette smoking. However, in clinic, not all smokers develop COPD. The underlying mechanism remains unclear. A549 cells, which are widely used in vitro as a model of alveolar type II pulmonary epithelium, were subjected to step-wise increasing cigarette smoke extract (CSE) treatments. Those cigarette smoke extract resistant (SER) cells were cultured and used for further experiments. The aim of this study is to investigate the differentially expressed genes in SER group with or without CSE treatment and identify potential genes or pathways which could play a role in COPD pathogenesis.
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| Overall design |
6 groups (2 genotypes x 3 time points), each with 4 biological replicates
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| Contributor(s) |
Wu C, Weissmann N, Wilhelm J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jan 16, 2023 |
| Last update date |
Jan 01, 2024 |
| Contact name |
Jochen Wilhelm |
| Organization name |
Justus-Liebig University Giessen
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| Department |
Institute for Lung Health
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| Lab |
ILH Genomics
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| Street address |
Aulweg 132
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| City |
Giessen |
| State/province |
Hessen |
| ZIP/Postal code |
35392 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL20844 |
Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Feature Number Version] |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA924293 |
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