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Series GSE223073 Query DataSets for GSE223073
Status Public on Aug 08, 2023
Title Characterization of early transcriptomic changes associated with hepatitis B virus exposure in human and macaque immune cell populations
Organisms Macaca fascicularis; Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Chronic hepatitis B virus (HBV) infection affects close to 300 million individuals worldwide, representing one of the major etiological factors for the development of cirrhosis and hepatocellular carcinoma (HCC). At the molecular level, the mechanisms behind chronic HBV infection are based on the persistence of the viral genome as an episomal structure termed covalently closed circular DNA (cccDNA), and the evasion of both innate and adaptive immune responses. Thus, it is considered that HBV cure will be a multi-layered combination approach of anti-viral and immune-boosting strategies. Although the development of potential HBV therapeutics has been hampered by the lack of suitable long-term infection models, the stark contrast between human and non-human primates regarding their immune responses and infection outcomes, represents an opportunity to identify the molecular mechanisms favoring HBV elimination. Therefore, we aimed to characterize the early transcriptomic changes associated with HBV exposure in human and macaque immune cell populations.
 
Overall design RNA-Seq profiles from T cells, B cells, myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) with our without HBV exposure (2 h). Experiments were performed for both human and macaque immune cell populations.
 
Contributor(s) Roca Suarez AA, Tamellini A, Porcheray F, Planel S, Couturier C, Reynier F, Tran T, Elie C, Saliou A, Baum C, Grand X
Citation(s) 37727809
Submission date Jan 17, 2023
Last update date Sep 27, 2023
Contact name Xavier Grand
E-mail(s) xavier.grand@ens-lyon.fr, xavier.grand@inserm.fr
Phone +33611221960
Organization name INSERM U1052, UCBL1, ENS de Lyon
Lab U1052, LBMC
Street address 46 allée d'Italie
City Lyon
ZIP/Postal code 69364
Country France
 
Platforms (2)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
GPL22523 Illumina NextSeq 500 (Macaca fascicularis)
Samples (90)
GSM6939220 14H Homo sapiens LB HBV Patient2 Batch4
GSM6939221 22H Homo sapiens LB HBV Patient3 Batch3
GSM6939222 30H Homo sapiens LB HBV Patient4 Batch4
Relations
BioProject PRJNA924796

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Supplementary file Size Download File type/resource
GSE223073_normalized_count_Homo_sapiens.csv.gz 4.3 Mb (ftp)(http) CSV
GSE223073_normalized_count_Macaca_fascicularis.csv.gz 2.0 Mb (ftp)(http) CSV
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