|
| Status |
Public on Jul 06, 2023 |
| Title |
Keratin 19 binds and regulates cytoplasmic HNRNPK mRNA targets in triple-negative breast cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
Other
|
| Summary |
This study identifies how a cytoskeletal protein can directly regulate gene expression by controlling the subcellular localization of RNA-binding proteins to support pathways involved in cancer progression.
|
| |
|
| Overall design |
We used parental and K19 KO cell lines to study the impact of cytoskeleton in gene expression regulation.
|
| |
|
| Contributor(s) |
Fallatah A, Anastasakis DG, Manzourolajdad A, Sharma P, Wang X, Jacob A, Alsharif S, Elgerbi A, Coulombe PA, Hafner M, Chung BM |
| Citation(s) |
37592256 |
| |
| Submission date |
Jan 24, 2023 |
| Last update date |
Oct 05, 2023 |
| Contact name |
Markus Hafner |
| E-mail(s) |
markus.hafner@nih.gov
|
| Organization name |
NIH
|
| Department |
NIAMS
|
| Lab |
Laboratory of Muscle Stem Cells and Gene Regulation
|
| Street address |
50 South Drive
|
| City |
Bethesda |
| State/province |
MD |
| ZIP/Postal code |
20892 |
| Country |
USA |
| |
|
| Platforms (2) |
|
| Samples (21)
|
|
| Relations |
| BioProject |
PRJNA926958 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE223603_KOV_KOF_gene_exp.diff.gz |
748.0 Kb |
(ftp)(http) |
DIFF |
| GSE223603_KOV_KONLS_gene_exp.diff.gz |
732.9 Kb |
(ftp)(http) |
DIFF |
| GSE223603_KOsicontrol_KOsiHNRNPK_gene_exp.diff.gz |
834.8 Kb |
(ftp)(http) |
DIFF |
| GSE223603_PF_KOF_gene_exp.diff.gz |
740.3 Kb |
(ftp)(http) |
DIFF |
| GSE223603_PV_KOV_gene_exp.diff.gz |
745.1 Kb |
(ftp)(http) |
DIFF |
| GSE223603_PV_PF_gene_exp.diff.gz |
738.5 Kb |
(ftp)(http) |
DIFF |
| GSE223603_PV_PNLS_gene_exp.diff.gz |
748.5 Kb |
(ftp)(http) |
DIFF |
| GSE223603_PdeltaNLS_KdeltaNLS_gene_exp.diff.gz |
740.5 Kb |
(ftp)(http) |
DIFF |
| GSE223603_PsiHNRNPK_KOsiHNRNPK_gene_exp.diff.gz |
841.1 Kb |
(ftp)(http) |
DIFF |
| GSE223603_Psicontrol_KOsicontol_gene_exp.diff.gz |
834.3 Kb |
(ftp)(http) |
DIFF |
| GSE223603_Psicontrol_PsiHNRNPK_gene_exp.diff.gz |
839.2 Kb |
(ftp)(http) |
DIFF |
| GSE223603_RAW.tar |
42.5 Mb |
(http)(custom) |
TAR (of CSV) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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