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| Status |
Public on Jun 17, 2010 |
| Title |
Analysis of micorRNA expression during the HBV acute and chronic infections |
| Platform organisms |
Homo sapiens; Mus musculus; Rattus norvegicus |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
Recent implication of microRNAs (miRNAs) in the intricate cross-talk between the host and the pathogen in viral infections reveals a new layer of mechanism for host-virus interactions. In the present study, we investigated human miRNAs which may be involved in the acute and chronic HBV infections via microarray profiling. We determined the global miRNA expression profiles elicited in the uninfected control model (HepG2), the acute infection model (HepG2 transfected with a 1.3 full-length HBV genome) and the chronic infection model (HepG2.2.15) using CapitalBio corporation’s mammalian miRNA arrays.
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| Overall design |
Three cellular models were used in this study: the human hepatoblastoma cell line HepG2 as a blank control representing the condition without virus infection; HepG2 transfected with a 1.3 full-length HBV genome as an acute infection model; and HepG2.2.15, a well-established cell line derived from HepG2 transfected with a full-length HBV genome and constitutively expressing HBV, as a chronic infection model.
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| Contributor(s) |
Zhang Z, Liu X, Wang D, Teng M, Niu L, Liang Z, Huang A |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jun 16, 2010 |
| Last update date |
Mar 22, 2012 |
| Contact name |
Wei Lan |
| Organization name |
University of Science and Technology of China
|
| Department |
School of Life Science
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| Street address |
96#, Jinzhai Road
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| City |
Hefei |
| State/province |
Anhui |
| ZIP/Postal code |
230027 |
| Country |
China |
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| Platforms (1) |
| GPL8469 |
Capitalbio mammal microRNA V3.0 |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA127645 |
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