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| Status |
Public on Dec 15, 2010 |
| Title |
Gene expression analysis of Merkel Cell Carcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Merkel cell carcinoma (MCC) is a polyomavirus-associated skin cancer that is frequently lethal and lacks established prognostic biomarkers. The purpose of this study was to use gene expression analysis to identify biomarkers that may improve prognostic accuracy and provide insight into MCC biology.
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| Overall design |
We profiled 35 tumors from 34 patients. Tumors were macrodissected from surrounding stroma. RNA isolation was performed with RNeasy or Allprep Mini kits (Qiagen, Alameda, CA), and RNA quality assessed by Agilent Bioanalyzer analysis. RNAs were profiled on the Human Rosetta Custom Affymetrix 2.0 chip.
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| Contributor(s) |
Paulson KG, Iyer JG, Schelter J, Cleary MA, Hardwick J, Nghiem P |
| Citation(s) |
21422430, 25116754 |
| |
| Submission date |
Jun 16, 2010 |
| Last update date |
Dec 08, 2014 |
| Contact name |
Michele Cleary |
| E-mail(s) |
michele_cleary@merck.com
|
| Phone |
215 652-6104
|
| Organization name |
Merck and Co., Inc.
|
| Department |
Genetics and Pharmacogenomics
|
| Lab |
Target & Pathway Biology
|
| Street address |
770 Sumneytown Pike
|
| City |
West Point |
| State/province |
PA |
| ZIP/Postal code |
19486 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL10379 |
Rosetta/Merck Human RSTA Custom Affymetrix 2.0 microarray [HuRSTA-2a520709] |
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| Samples (35)
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| Relations |
| BioProject |
PRJNA128667 |
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