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| Status |
Public on Mar 04, 2024 |
| Title |
Development of gene expression signatures in whole spectrum of leprosy |
| Organism |
Mycobacterium leprae |
| Experiment type |
Expression profiling by array
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| Summary |
To further development of our gene expression approach in different groups of leprosy, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish leprosy reactions and relapse cases from healthy controls. Human biopsy and skin slit were collected from reaction cases, PB cases, MB cases, relapse cases and healthy contacts. Total 1891,1384, 1134, 475 and 762 no of genes were overexpressed in PB, T1R, T2R, LL and relapse cases respectively. Expression of seven genes (glcB, infB, ftsH, ppgk,relA, rpsR and atpB) from relapse cases was quantified in the same RNA samples by real-time PCR confirming role of theses genes in relapse cases.
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| Overall design |
Agilent one-color experiment,Organism: Mycobacterium leprae Agilent Microarray Gene Expression 8x15K Arrays AMADID: 84765
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| Contributor(s) |
Singh I, Lavania M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Feb 07, 2023 |
| Last update date |
Mar 04, 2024 |
| Contact name |
Genotypic technology |
| E-mail(s) |
sudha.rao@genotypic.co.in
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| Organization name |
Genotypic Technology
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| Street address |
259, Apoorva 4th cross,80 feet Road,RMV 2ND STAGE
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| City |
Bangalore |
| State/province |
Karnataka |
| ZIP/Postal code |
560094 |
| Country |
India |
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| Platforms (1) |
| GPL33105 |
Mycobacterium leprae Agilent Microarray Gene Expression 8x15K Arrays AMADID: 84765 |
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| Samples (45)
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| Relations |
| BioProject |
PRJNA932323 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE224736_RAW.tar |
97.2 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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