|
| Status |
Public on Nov 28, 2023 |
| Title |
Transcriptional responses of the human dorsal striatum in opioid use disorder implicates cell type-specifc programs |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Gene expression profile at single cell level of striatal cells from the caudate nucleus and putamen in postmortem human brains of unaffected individuals or those with opioid use disorder.
|
| |
|
| Overall design |
Case-cohort matched postmortem human brain single nucleus RNA-seq of the caudate nucleus and putamen of individuals with and without opioid use disorder
|
| |
|
| Contributor(s) |
Ray MH, Phan BN, Pfenning AR, Logan RW |
| Citation(s) |
38296993 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| F30 DA053020 |
Integrating primate-rodent cell types and epigenomics to identify conservation in substance addiction |
CARNEGIE MELLON UNIVERSITY |
BaDoi Nguyen Phan |
| R01 DA051390 |
Molecular rhythm alterations in human post-mortem brain associated with opioid use disorder |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
Ryan W Logan |
| R01 DA051390 |
Molecular rhythm alterations in human post-mortem brain associated with opioid use disorder |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
Marianne L Seney |
| R01 HL150432 |
Cell-type specific role of circadian-dependent transcription in fentanyl-induced synaptic and behavioral plasticity - Supplement |
UNIVERSITY OF PITTSBURGH AT PITTSBURGH |
Ryan W Logan |
| DP1 DA046585 |
Interpreting the regulatory mechanisms underlying the predisposition to substance use disorders |
CARNEGIE MELLON UNIVERSITY |
Andreas Robert Pfenning |
|
| |
| Submission date |
Feb 13, 2023 |
| Last update date |
Feb 14, 2024 |
| Contact name |
BaDoi Nguyen Phan |
| E-mail(s) |
badoi.phan@pitt.edu
|
| Organization name |
Carnegie Mellon University
|
| Department |
Computational Biology
|
| Lab |
Pfenning Lab
|
| Street address |
5000 Forbes Ave
|
| City |
Pittsburgh |
| State/province |
PA |
| ZIP/Postal code |
15213 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (24)
|
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| This SubSeries is part of SuperSeries: |
| GSE233279 |
Single nuclei transcriptomics of human and monkey striatum implicates DNA damage, neuroinflammation, and neurodegeneration signaling in opioid use disorder |
|
| Relations |
| BioProject |
PRJNA934272 |
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