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Series GSE225176 Query DataSets for GSE225176
Status Public on Jun 20, 2023
Title ELL3 promotes stem cell native to primed transition through LINE-based enhancers [ATAC-seq]
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Long interspersed nuclear elements-1 (LINE-1) are the clade of retrotransposons still possessing autonomous mobility in mammals. LINE-1 transcription contributed to global chromatin opening in mouse early embryos.Whether LINE-1 element plays a direct role in the local regulation of its nearby genes remains largely obscure.ELL3 occupies and represses the youngest LINE-1 family members L1Md_T and L1Md_Gf in naïve mouse ES cells.We found that the enhancer function of the evolutionally young LINE-1s, and suggests that ELL3 act as a key drivers of the naïve-primed transition through regulating the young LINE-1 based enhancers.
Overall design ATAC-seq
Contributor(s) Liu X, Lin C
Citation(s) 37591949
Submission date Feb 13, 2023
Last update date Sep 25, 2023
Contact name Xiaoxu Liu
Organization name Southeast University
Department Institute of Life Sciences
Lab the Key Laboratory of Developmental Genes and Human Disease
Street address 2 Sipailou
City Nanjing
State/province Jiangsu
ZIP/Postal code 210018
Country China
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (2)
GSM7040754 ATAC-seq in WT
GSM7040755 ATAC-seq in Ell3 KO
This SubSeries is part of SuperSeries:
GSE208227 ELL3 promotes stem cell native to primed transition through LINE-based enhancers
BioProject PRJNA934293

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Supplementary file Size Download File type/resource
GSE225176_RAW.tar 274.9 Mb (http)(custom) TAR (of BW)
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Raw data are available in SRA
Processed data provided as supplementary file

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